Epigallocatechin gallate has antibacterial and antibiofilm activity in methicillin resistant and susceptible of different lineages in non-cytotoxic concentrations.

is an opportunistic agent that can cause a variety of infections, both hospital and community-acquired. Epigallocatechin gallate (EGCG), a flavonoid present in the leaves of , has different biological activities, including antimicrobial potential. Here we evaluate the antibacterial and antibiofilm potential of EGCG in nine clinical strains of with different genetic profile and antimicrobial susceptibilities. The minimum inhibitory concentrations (MIC) of EGCG ranged from 7.81 to 62.5 μg/mL, and bactericidal activity was observed at 4 times the MIC. Sub-inhibitory concentrations were able to inhibit biofilm production. Concentrations ≤62.5 μg/mL of EGCG were non-cytotoxic for murine macrophages. EGCG significantly reduced the mortality of infected larvae with the , having shown relevant antibiofilm properties and efficacy in inhibiting the growth of different clinical isolates of , thus being a promising substance for the treatment of infections caused by this agent.