Medical School of Nantong University, Nantong, Jiangsu, China.
Center for Basic Medical Research, Medical School of Nantong University, Nantong, Jiangsu, China.
Front Cell Infect Microbiol. 2023 Apr 6;13:1119037. doi: 10.3389/fcimb.2023.1119037. eCollection 2023.
With the irrational use of antibiotics and the increasing abuse of oral antibiotics, the drug resistance of gastrointestinal pathogens has become a prominent problem in clinical practice. Gut microbiota plays an important role in maintaining human health, and the change of microbiota also affects the activity of pathogenic bacteria. Interfering with antibiotic resistant bacteria by affecting gut microbiota has also become an important regulatory signal. In clinical application, due to the unique advantages of traditional Chinese medicine in sterilization and drug resistance, it is possible for traditional Chinese medicine to improve the gut microbial microenvironment. This review discusses the strategies of traditional Chinese medicine for the treatment of drug-resistant bacterial infections by changing the gut microenvironment, unlocking the interaction between microbiota and drug resistance of pathogenic bacteria.
随着抗生素的不合理使用和口服抗生素的滥用，胃肠道病原体的耐药性已成为临床实践中的突出问题。肠道微生物群在维持人体健康方面发挥着重要作用，微生物群的变化也会影响致病菌的活性。通过影响肠道微生物群来干扰耐药菌也成为一种重要的调节信号。在临床应用中，由于中药在杀菌和耐药方面具有独特的优势，因此中药有可能改善肠道微生物微环境。本综述讨论了通过改变肠道微环境来治疗耐药菌感染的中药策略，揭示了微生物群与致病菌耐药性之间的相互作用。
