Phero J C, Prithvi Raj P, Knarr D, Turner P, Denson D D, Vigdorth E, Edstrom H H
Anesth Prog. 1987 Sep-Oct;34(5):187-90.
Bupivacaine in dosages of 20, 40, 60, or 80 mg was applied by spray to the oropharynx of 24 volunteers. Blood levels of bupivacaine were detectable at 10 minutes, peaked at 60-90 minutes, and were still measurable at 150 minutes after administration. The maximum bupivacaine plasma level recorded in any volunteer was 0.96 -g/mL (after 80 mg). Increase in pulse rate and decrease in systolic blood pressure were significantly correlated with increasing bupivacaine dosage. No clinical signs or symptoms of drug toxicity were observed in any subject.
将20毫克、40毫克、60毫克或80毫克剂量的布比卡因通过喷雾方式应用于24名志愿者的口咽部。给药后10分钟可检测到布比卡因的血药浓度，60 - 90分钟达到峰值，150分钟时仍可测得。任何一名志愿者记录到的布比卡因血浆最高浓度为0.96微克/毫升（80毫克剂量后）。脉搏率增加和收缩压降低与布比卡因剂量增加显著相关。未在任何受试者中观察到药物毒性的临床体征或症状。
