Akerman S B
Br J Anaesth. 1975 Sep;47(9):923-7. doi: 10.1093/bja/47.9.923.
The surface local anaesthetic properties of the new local anaesthetic amid etidocaine (Duranest) were studied in experimental animals. Etidocaine produced topical local anaesthesia of high intensity, rapid onset and with a comparatively long duration of action following corneal, intranasal and intratracheal application. The surface anaesthetic activity of etidocaine was substantially greater than that of lignocaine, similar to that of bupivacaine but less than that of amethocaine. When applied to the mucous surfaces of the nose and the respiratory tract, etidocaine was less toxic than amethocaine and bupivacaine but more toxic than lignocaine. The data justify a clinical evaluation of etidocaine as a surface anaesthetic.
在实验动物中研究了新型局部麻醉药酰胺依替卡因（杜拉耐斯特）的表面局部麻醉特性。依替卡因在角膜、鼻内和气管内应用后可产生高强度、起效迅速且作用持续时间相对较长的局部表面麻醉。依替卡因的表面麻醉活性明显大于利多卡因，与布比卡因相似但小于丁卡因。当应用于鼻和呼吸道的黏膜表面时，依替卡因的毒性低于丁卡因和布比卡因，但高于利多卡因。这些数据证明对依替卡因作为表面麻醉药进行临床评估是合理的。
