Faculty of Nutrition, Federal University of Goias, Goiânia, Brazil.
Faculty of Nutrition, Federal University of Goias, Goiânia, Brazil.
Biomed Pharmacother. 2022 Jan;145:112289. doi: 10.1016/j.biopha.2021.112289. Epub 2021 Nov 17.
Ursolic acid (UA) is a natural compound that shows anti-inflammatory actions. However, no human studies have investigated the cytokine profile during the RT and UA consumption. The purpose of this study was to verify if UA is able to potentiate the anti-inflammatory activity after RT, reflecting in the reduction of blood inflammatory markers in healthy men. Twenty-seven participants were allocated to two groups: control (CON) (n = 13) and UA (n = 14). For 8weeks, each group performed RT and consumed capsules containing a placebo (400 mg/day) or UA (400 mg/day). Serum cytokine concentrations were evaluated before and after the training period. There was no difference in the serum cytokine concentrations of TNF-α, IL-10 and IL-6 (p > 0.05). In conclusion, UA supplementation for 8weeks was not able to change the blood TNF-α, IL-10, and IL-6 concentrations in healthy men undergoing RT. However, further studies are warranted to investigate other inflammatory markers.
熊果酸（UA）是一种具有抗炎作用的天然化合物。然而，目前还没有人类研究调查过 RT 和 UA 摄入期间的细胞因子谱。本研究旨在验证 UA 是否能够增强 RT 后的抗炎活性，从而反映在健康男性的血液炎症标志物减少上。27 名参与者被分配到两组：对照组（CON）（n=13）和 UA 组（n=14）。在 8 周的时间里，每组都进行 RT 并服用含有安慰剂（400mg/天）或 UA（400mg/天）的胶囊。在训练期间前后评估血清细胞因子浓度。TNF-α、IL-10 和 IL-6 的血清细胞因子浓度没有差异（p>0.05）。总之，UA 补充 8 周不能改变接受 RT 的健康男性的血液 TNF-α、IL-10 和 IL-6 浓度。然而，需要进一步的研究来调查其他炎症标志物。
