Institute of Sport Sciences and Physiotherapy, University of Tartu, 18 Ülikooli St., 50090 Tartu, Estonia.
Department of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50090 Tartu, Estonia.
Nutrients. 2022 Dec 13;14(24):5302. doi: 10.3390/nu14245302.
Data on the effect of vitamin D (Vit-D) supplementation on cardiorespiratory fitness (VO2max) are conflicting. A possible source of discrepancies in the literature is the heterogeneity in baseline Vit-D status among participants in previous studies. The main objectives of the present study were to assess the impact of Vit-D supplementation on VO2max and inflammatory status in Vit-D deficient young healthy men. Participants (n = 39, baseline serum Vit-D level < 50 nmol/L) were quasi-randomly assigned to one of the two groups, which, in a double-blind manner, supplemented their diet daily with either Vit-D (8000 IU; VD) or placebo (PLC) and concomitantly performed a 12-week supervised resistance training program. During the 12-week intervention, serum Vit-D concentrations increased 3.9-fold (p < 0.001) in the VD group while no changes occurred in the PLC group. Baseline VO2max did not differ in the two groups and remained unchanged during the intervention. Serum interleukin-10/tumour necrosis factor alpha ratio increased significantly (30%, p = 0.007; effect size 0.399) in VD but not in PLC group. In conclusion, 12-week Vit-D supplementation increases serum 25(OH)D levels and improves inflammatory status, but has no impact on VO2max in Vit-D deficient young men engaged in resistance training.
关于维生素 D（Vit-D）补充对心肺功能适应性（VO2max）的影响，相关数据存在争议。文献中存在差异的一个可能原因是，先前研究中参与者的基础 Vit-D 状态存在异质性。本研究的主要目的是评估 Vit-D 补充对 Vit-D 缺乏的年轻健康男性的 VO2max 和炎症状态的影响。参与者（n = 39，基线血清 Vit-D 水平 < 50 nmol/L）被随机分为两组，以双盲方式每日补充饮食中的 Vit-D（8000 IU；VD）或安慰剂（PLC），并同时进行为期 12 周的监督阻力训练计划。在 12 周的干预期间，VD 组血清 Vit-D 浓度增加了 3.9 倍（p < 0.001），而 PLC 组没有变化。两组的基线 VO2max 没有差异，并且在干预期间保持不变。血清白细胞介素-10/肿瘤坏死因子-α 比值在 VD 组显著增加（30%，p = 0.007；效应大小 0.399），但在 PLC 组没有增加。总之，12 周的 Vit-D 补充可增加血清 25(OH)D 水平并改善炎症状态，但对进行阻力训练的 Vit-D 缺乏年轻男性的 VO2max 没有影响。
