Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan, China.
Chengdu University of Traditional Chinese Medicine, Sichuan, China.
Pak J Pharm Sci. 2021 Jul;34(4):1351-1358.
Allergic rhinitis (AR) is one of the most common atopic disorders, which seriously affects patients' quality of life. Yupingfeng (YPF) Power is a traditional Chinese herb formula, and its oral dosage form has been widely used for the treatment of AR in Asian countries. In this study, we investigated the effects of YPF nasal drops on ovalbumin (OVA) sensitized/stimulated allergic rhinitis in rats. A Sprague-Dawley (SD) rat model of OVA-induced AR was established and then treated with three doses of YPF nasal drops. Besides, histopathological features, eosinophil cationic protein (ECP) in the nasal mucosa, and expression of type 1 helper T (Th1)/type 2 helper T (Th2)-related cytokines in serum were analyzed. The results showed that YPF nasal drops alleviated the injury of nasal mucosal epithelial structure, promoted the recovery of ciliary morphology and function and reduced interstitial edema and inflammatory cell infiltration to some extent. Moreover, YPF nasal drops regulated imbalance in Th1/Th2 cells caused by AR via regulating downward the expression of interleukin 4 (IL-4) and adjusting upward the expression of interferon-γ (INF-γ), and interleukin 12 (IL-12). Furthermore, it inhibited the expression of ECP in nasal epithelial eosinophil-specific granules. The findings of this study provided a new perspective for the treatment of AR with YPF nasal drops based on Traditional Chinese Medicine.
变应性鼻炎（AR）是最常见的特应性疾病之一，严重影响患者的生活质量。玉屏风（YPF）散是一种中药方剂，其口服剂型已在亚洲国家广泛用于治疗 AR。在这项研究中，我们研究了玉屏风滴鼻剂对卵清蛋白（OVA）致敏/刺激的变应性鼻炎大鼠的作用。建立了OVA 诱导的 AR 大鼠模型，然后用三种剂量的玉屏风滴鼻剂进行治疗。此外，还分析了鼻黏膜组织病理学特征、嗜酸性粒细胞阳离子蛋白（ECP）和血清中 1 型辅助 T（Th1）/2 型辅助 T（Th2）相关细胞因子的表达。结果表明，玉屏风滴鼻剂可减轻鼻黏膜上皮结构损伤，促进纤毛形态和功能恢复，在一定程度上减轻间质水肿和炎症细胞浸润。此外，玉屏风滴鼻剂通过下调白细胞介素 4（IL-4）的表达和上调干扰素-γ（INF-γ）、白细胞介素 12（IL-12）的表达，调节 AR 引起的 Th1/Th2 细胞失衡，并抑制鼻上皮嗜酸性粒细胞特异性颗粒中 ECP 的表达。这项研究的结果为基于中药的玉屏风滴鼻剂治疗 AR 提供了新的视角。
