Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.
Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK
BMJ Case Rep. 2021 Nov 19;14(11):e243773. doi: 10.1136/bcr-2021-243773.
A 53-year-old woman presented with a 25-year history of acne excoriée and prurigo excoriée. Her symptoms began in 1988 coinciding with her husband's death from a brain tumour when she was 27. The pruritus affected her quality of life and disturbed her sleep. She had scarring on her face and body resulting from persistent scratching. The pruritus proved refractory to treatment despite a multi-modal treatment approach including multiple topicals, phototherapy and systemic agents such as isotretinoin, antibiotics, anxiolytic agents and neuromodulators. She was extremely frustrated that various treatments had been ineffective at controlling the itch-scratch cycle. She was commenced on low dose naltrexone (LDN), 3 mg nocte, and she became itch free within a few weeks. She reports that the LDN has had a beneficial impact on her quality of life.
一位 53 岁女性，因 25 年的撕剥性痤疮和瘙痒性搔抓症就诊。她的症状始于 1988 年，当时她 27 岁，丈夫因脑瘤去世。瘙痒影响了她的生活质量并扰乱了她的睡眠。她因持续搔抓而在面部和身体上留下了疤痕。尽管采用了包括多种局部治疗、光疗和全身药物治疗（如异维 A 酸、抗生素、抗焦虑药物和神经调节剂）在内的多模式治疗方法，但瘙痒仍未得到缓解。她对各种治疗方法均未能控制瘙痒-搔抓循环感到非常沮丧。她开始接受低剂量纳曲酮（LDN）治疗，每晚 3 毫克，数周内瘙痒即消失。她报告说，LDN 对她的生活质量有有益的影响。
