Department of Ophthalmology and Micro-Technology, Yokohama City University, Kanagawa, Japan.
Department of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Eye (Lond). 2022 Dec;36(12):2247-2252. doi: 10.1038/s41433-021-01818-1. Epub 2021 Nov 19.
To compare the foveal microstructures, such as the prevalence of epiretinal proliferation (EP) and residual ellipsoid zone (EZ), in eyes with lamellar macular hole (LMH), epiretinal retinal membrane (ERM) foveoschisis and macular pseudohole (MPH), and to investigate the association of the foveal microstructure with visual functions.
In addition to the prevalence of EP, we calculated the residual EZ index within 1mm and 3 mm (rEZ1 and rEZ3) in all examined eyes. Comparisons were conducted to baseline characteristics (logMAR visual acuity [logMAR VA], metamorphopsia score [Mave], central retinal thickness [CRT], the prevalence of EP, rEZ1 and rEZ3) between MPH, ERM foveoschisis and LMH subgroups. The relationships (1) between logMAR VA and each of age, type (MPH, ERM foveoschisis and LMH), the prevalence of EP, rEZ1, rEZ3, spherical equivalent (SE) and CRT and (2) between Mave and each of variables were investigated.
Fifty-one eyes of 48 patients were enroled. The mean age was 65.2 ± 11.1 years. Ten eyes were diagnosed as LMH, 22 eyes as ERM foveoschisis and 19 eyes as MPH, respectively. There was a significant difference in CRT only between LMH and ERM foveoschisis (p = 0.023). There was a tendency toward significance in rEZ1 between LMH and ERM foveoschisis (p = 0.057), but not in rEZ3. The optimal model for logMAR VA included age, rEZ1, SE and CRT. On the other hand, the optimal model for Mave included the prevalence of EP, rEZ1 and SE.
Microstructural observations are useful to predict visual functions in LMH, ERM foveoshisis and MPH.
比较板层黄斑裂孔（LMH）、视网膜内界膜（ERM）劈裂和假性黄斑裂孔（MPH）眼中的黄斑中心凹微观结构，如视网膜前增殖（EP）和残留椭圆体带（EZ）的发生率，并探讨这些微观结构与视力功能的关系。
除 EP 的发生率外，我们还计算了所有检查眼内 1mm 和 3mm 范围内的残留 EZ 指数（rEZ1 和 rEZ3）。比较了 MPH、ERM 劈裂和 LMH 亚组之间的基线特征（logMAR 视力[logMAR VA]、变形分数[Mave]、中心视网膜厚度[CRT]、EP 发生率、rEZ1 和 rEZ3）。分析了 logMAR VA 与年龄、类型（MPH、ERM 劈裂和 LMH）、EP 发生率、rEZ1、rEZ3、等效球镜（SE）和 CRT 之间的关系（1），以及 Mave 与各变量之间的关系（2）。
共纳入 48 例 51 只眼。平均年龄为 65.2±11.1 岁。10 只眼诊断为 LMH，22 只眼诊断为 ERM 劈裂，19 只眼诊断为 MPH。仅在 LMH 和 ERM 劈裂之间 CRT 存在显著差异（p=0.023）。在 LMH 和 ERM 劈裂之间，rEZ1 有显著趋势（p=0.057），但 rEZ3 无显著差异。logMAR VA 的最佳模型包括年龄、rEZ1、SE 和 CRT。另一方面，Mave 的最佳模型包括 EP 发生率、rEZ1 和 SE。
微观结构观察对于预测 LMH、ERM 劈裂和 MPH 中的视力功能是有用的。
