Rino Frisina, Elena Zampedri, Ivan Marchesoni, Paolo Bosio, Barbara Parolini, Federica Romanelli
Multizonal Unit of Ophthalmology of Autonomous Province of Trento (TN), Square Santa Maria n. 6, 38068, Rovereto, Trento, Italy.
Department of Ophthalmology of Sant'Anna Institute, Brescia, BS, Italy.
Graefes Arch Clin Exp Ophthalmol. 2016 Nov;254(11):2141-2150. doi: 10.1007/s00417-016-3371-5. Epub 2016 Apr 28.
To study morphological and functional characteristics of myopic lamellar macular hole (LMH) with posterior staphyloma.
Retrospective observational longitudinal study. Forty myopic eyes affected by LMH and posterior staphyloma have been examined. Pathological myopia was defined as axial length equal or superior to 26.5 mm. LMH was defined on the basis of the following characteristics: irregular foveal contour, inner retinal defect with or without intraretinal splitting and absence of full thickness retinal defect. Demographic and functional parameters were: age, sex, status of lens and best corrected visual acuity (BCVA). Tomographic parameters were: type of LMH, macular retinoschisis (MRS), posterior vitreous detachment (PVD), type of epiretinal membrane (ERM), integrity of ellipsoid zone (EZ) and external limiting membrane (ELM), residual foveal thickness (RFT) and maximal diameter of intraretinal splitting (MDIRS).
The statistical analysis showed a significant prevalence of posterior vitreous adherence in the atypical ERM subgroup (P = 0.001). EZ (P = 0.006) and ELM (P = 0.007) damages were significantly associated with the atypical ERM subgroup. RFT was statistically lower in the atypical ERM subgroup compared to the conventional ERM subgroup (P = 0.015). During the follow-up, the statistical analysis showed a significant reduction of RFT in the atypical ERM subgroup (P = 0.041).
Myopic lamellar macular hole (LMH) associated with atypical ERM is a more severe clinical entity than myopic LMH associated with conventional ERM.
研究伴有后巩膜葡萄肿的近视性板层黄斑裂孔（LMH）的形态学和功能特征。
回顾性观察性纵向研究。对40只患有LMH和后巩膜葡萄肿的近视眼进行了检查。病理性近视定义为眼轴长度等于或大于26.5毫米。LMH根据以下特征定义：中央凹轮廓不规则、存在或不存在视网膜内劈裂的视网膜内层缺损以及无全层视网膜缺损。人口统计学和功能参数包括：年龄、性别、晶状体状态和最佳矫正视力（BCVA）。断层扫描参数包括：LMH类型、黄斑视网膜劈裂（MRS）、玻璃体后脱离（PVD）、视网膜前膜（ERM）类型、椭圆体带（EZ）和外界膜（ELM）的完整性、残留中央凹厚度（RFT）和视网膜内劈裂的最大直径（MDIRS）。
统计分析显示，非典型ERM亚组中玻璃体后粘连的发生率显著更高（P = 0.001）。EZ（P = 0.006）和ELM（P = 0.007）损伤与非典型ERM亚组显著相关。与传统ERM亚组相比，非典型ERM亚组的RFT在统计学上更低（P = 0.015）。在随访期间，统计分析显示非典型ERM亚组的RFT显著降低（P = 0.041）。
与非典型ERM相关的近视性板层黄斑裂孔（LMH）是一种比与传统ERM相关的近视性LMH更严重的临床实体。
