Department of Internal Medicine, Gazi University, Ankara, Turkey.
Department of Medical Oncology, Gazi University, Ankara, Turkey.
J Gastrointest Cancer. 2023 Mar;54(1):264-267. doi: 10.1007/s12029-021-00761-4. Epub 2021 Nov 20.
Krukenberg tumors are among rare cases of metastatic ovary cancers. They are presented as a solid mass which generally has bilateral and sometimes cystic components and is also known through symptoms related to the mass effect and/or hormonal imbalance. However, they may present findings before the primary tumor or remain asymptomatic for a long time.
We presented a patient, who was diagnosed with gallbladder cancer nine years ago and whose adjuvant treatment was completed, applied to the outpatient clinic with the complaint of vaginal bleeding. Surgery was recommended to the patient and the patient was diagnosed with metastatic signet ring cell gallbladder cancer. The patient was started on gemcitabine-capecitabine treatment after surgery.
The case is important both due to the rareness of metastasis of gall bladder cancer on the ovaries and also the detection of metastasis following the nine-year recurrence-free period. This case shows that routine controls including a careful gynecological examination in a patient primarily detected to have gastrointestinal malignity are important for recognizing late metastases.
库肯勃氏瘤是罕见的卵巢转移癌之一。它表现为实性肿块,通常具有双侧,有时还具有囊性成分,也与肿块效应和/或激素失衡相关的症状有关。然而,它们可能在原发肿瘤之前出现表现,或者长期无症状。
我们报告了一例患者,该患者九年前被诊断为胆囊癌,辅助治疗已完成,因阴道出血就诊于门诊。建议对患者进行手术,诊断为转移性印戒细胞胆囊癌。手术后,患者开始接受吉西他滨-卡培他滨治疗。
该病例很重要,不仅因为胆囊癌转移至卵巢非常罕见,而且在无复发生存期九年之后才发现转移。该病例表明,对于最初被诊断为胃肠道恶性肿瘤的患者,常规检查(包括仔细的妇科检查)对于识别晚期转移非常重要。