头颈部癌症患者治疗前的神经认知和感知言语缺陷的流行率：与人口统计学、行为和疾病相关因素的关联。
Prevalence of neurocognitive and perceived speech deficits in patients with head and neck cancer before treatment: Associations with demographic, behavioral, and disease-related factors.
机构信息
Department of Medical Psychology, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognition, Radboud University, Nijmegen, the Netherlands.
出版信息
Head Neck. 2022 Feb;44(2):332-344. doi: 10.1002/hed.26930. Epub 2021 Nov 19.
BACKGROUND
Neurocognition and speech, relevant domains in head and neck cancer (HNC), may be affected pretreatment. However, the prevalence of pretreatment deficits and their possible concurrent predictors are poorly understood.
METHODS
Using an HNC prospective cohort (Netherlands Quality of Life and Biomedical Cohort Study, N ≥ 444) with a cross-sectional design, we investigated the estimated prevalence of pretreatment deficits and their relationship with selected demographic, behavioral, and disease-related factors.
RESULTS
Using objective assessments, rates of moderate-to-severe neurocognitive deficit ranged between 4% and 8%. From patient-reported outcomes, 6.5% of patients reported high levels of cognitive failures and 46.1% reported speech deficits. Patient-reported speech functioning was worse in larynx compared to other subsites. Other nonspeech outcomes were unrelated to any variable. Patient-reported neurocognitive and speech functioning were modestly correlated, especially in the larynx group.
CONCLUSIONS
These findings indicate that a subgroup of patients with HNC shows pretreatment deficits, possibly accentuated in the case of larynx tumors.
背景
神经认知和言语是头颈部癌症（HNC）相关的领域，它们可能会受到治疗前的影响。然而，目前对于治疗前缺陷的普遍程度及其可能的并发预测因素还了解甚少。
方法
我们采用了头颈部癌症的前瞻性队列研究（荷兰生活质量和生物医学队列研究，N≥444），并采用了横断面设计，研究了治疗前缺陷的估计患病率及其与选定的人口统计学、行为和疾病相关因素的关系。
结果
使用客观评估，中度至重度神经认知缺陷的发生率在 4%至 8%之间。从患者报告的结果来看，6.5%的患者报告有较高水平的认知失败，46.1%的患者报告有言语缺陷。与其他部位相比，喉癌患者的患者报告的言语功能更差。其他非言语结果与任何变量均无关。患者报告的神经认知和言语功能呈中度相关，尤其是在喉癌组中。
结论
这些发现表明，一部分 HNC 患者在治疗前存在缺陷，在喉癌的情况下可能更为明显。
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