Roh Youkyung S, Huang Amy H, Sutaria Nishadh, Choi Una, Wongvibulsin Shannon, Choi Justin, Bordeaux Zachary A, Parthasarathy Varsha, Deng Junwen, Patel Deepa P, Canner Joseph K, Grossberg Anna L, Kwatra Shawn G
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
J Am Acad Dermatol. 2022 Apr;86(4):835-845. doi: 10.1016/j.jaad.2021.11.014. Epub 2021 Nov 18.
Atopic dermatitis (AD) is a pruritic, inflammatory skin disease associated with various comorbidities. However, comprehensive analyses of real-world comorbidities in adult patients with AD are limited.
To characterize the real-world comorbidities associated with adult AD in an ambulatory population.
We queried the MarketScan Commercial Claims and Encounters database from January 1, 2017 to December 31, 2017. Multivariable logistic regressions were performed to compare comorbidities in adult patients with AD versus age- and sex-matched controls.
A total of 39,779 patients with AD and 353,743 controls were identified. Increased odds of psychiatric conditions, including anxiety (odds ratio [OR] 1.44) and mood disorders (OR 1.31), were observed in patients with AD. Patients with AD had higher likelihoods of autoimmune diseases, including vitiligo (OR 4.44) and alopecia areata (OR 6.01). Adult AD was also associated with infections, including impetigo (OR 9.72), methicillin-resistant Staphylococcus aureus (OR 3.92), and cellulitis (OR 2.52). Patients with AD were more likely to have systemic conditions, including lymphoid/hematopoietic malignancy (OR 1.91), atherosclerosis (OR 1.69), and metabolic syndrome (OR 1.47). For all the above, P < .001.
Retrospective analysis of health care claims data.
Adult AD is associated with various psychiatric and systemic comorbidities, emphasizing the systemic nature of AD and the need for the collaborative management of these patients.
特应性皮炎（AD）是一种伴有多种合并症的瘙痒性炎症性皮肤病。然而，对成年AD患者真实世界合并症的全面分析有限。
描述门诊人群中成年AD患者的真实世界合并症。
我们查询了2017年1月1日至2017年12月31日的MarketScan商业索赔和病历数据库。进行多变量逻辑回归以比较成年AD患者与年龄和性别匹配的对照组的合并症。
共识别出39779例AD患者和353743例对照。在AD患者中观察到精神疾病的几率增加，包括焦虑症（优势比[OR]1.44）和情绪障碍（OR 1.31）。AD患者患自身免疫性疾病的可能性更高，包括白癜风（OR 4.44）和斑秃（OR 6.01）。成年AD还与感染相关，包括脓疱病（OR 9.72）、耐甲氧西林金黄色葡萄球菌（OR 3.92）和蜂窝织炎（OR 2.52）。AD患者更有可能患有全身性疾病，包括淋巴/造血系统恶性肿瘤（OR 1.91）、动脉粥样硬化（OR 1.69）和代谢综合征（OR 1.47）。对于上述所有情况，P <.001。
对医疗保健索赔数据的回顾性分析。
成年AD与多种精神和全身性合并症相关，强调了AD的全身性本质以及对这些患者进行协同管理的必要性。
