高密度脂蛋白蛋白质组观察：研究综合分析带来对高密度脂蛋白功能的新认识。
The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function.
机构信息
Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45237, United States of America.
Department of Pediatrics, Division of Endocrinology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH 45229, United States of America.
出版信息
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159072. doi: 10.1016/j.bbalip.2021.159072. Epub 2021 Nov 18.
PURPOSE OF REVIEW
High density lipoproteins (HDL) are a heterogeneous family of particles that contain distinct complements of proteins that define their function. Thus, it is important to accurately and sensitively identify proteins associated with HDL. Here we highlight the HDL Proteome Watch Database which tracks proteomics studies from different laboratories across the world.
RECENT FINDINGS
In 45 published reports, almost 1000 individual proteins have been detected in preparations of HDL. Of these, 251 have been identified in at least three different laboratories. The known functions of these consensus HDL proteins go well beyond traditionally recognized roles in lipid transport with many proteins pointing to HDL functions in innate immunity, inflammation, cell adhesion, hemostasis and protease regulation, and even vitamin and metal binding.
SUMMARY
The HDL proteome derived across multiple studies using various methodologies provides confidence in protein identifications that can offer interesting new insights into HDL function. We also point out significant issues that will require additional study going forward.
综述目的
高密度脂蛋白 (HDL) 是一类异质的颗粒，其中含有不同的蛋白质，这些蛋白质决定了它们的功能。因此，准确、灵敏地识别与 HDL 相关的蛋白质非常重要。本文重点介绍了 HDL 蛋白质组观察数据库，该数据库跟踪来自世界各地不同实验室的蛋白质组学研究。
最近的发现
在 45 篇已发表的报告中，在 HDL 的制备物中已经检测到近 1000 种不同的蛋白质。其中，至少有 251 种在三个不同的实验室中被鉴定出来。这些公认的 HDL 蛋白质的已知功能远远超出了传统上在脂质转运方面的作用，许多蛋白质表明 HDL 在先天免疫、炎症、细胞黏附、止血和蛋白酶调节，甚至维生素和金属结合方面具有功能。
总结
使用多种方法从多项研究中获得的 HDL 蛋白质组提供了对蛋白质鉴定的信心，这可以为 HDL 功能提供有趣的新见解。我们还指出了未来需要进一步研究的重要问题。
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