Peters G B, MacCormac L B
Genetics Department, Queen Elizabeth Hospital, Woodville, SA.
Cytogenet Cell Genet. 1987;45(3-4):141-7. doi: 10.1159/000132445.
A system is proposed whereby human karyotype data is expressed in quantitative terms rather than in the ISCN (1985) terminology used at present. This recoding facilitates application of multivariate analysis using standard statistical packages. As an example, karyotypes of 714 cases from 11 leukemias (Mitelman, 1983) are here recorded and subjected to discriminant analysis (SPSSx, 1983). Significant karyotypic specificity is apparent in six of the 11 FAB leukemia types. Four others show insignificant levels of specificity, while the last is equivocal. These results merely confirm present views. However, their generation by means of computerized multivariate analysis is novel, and confirms the feasibility of the approach. In this quantitative form, karyotypic data may be combined with any other data of diagnostic or prognostic value. Given such a consolidated data set, desired information concerning any aspect of neoplasia could be extracted via a single procedure.
本文提出了一种系统，通过该系统，人类核型数据以定量方式表示，而非目前使用的国际人类细胞遗传学命名法（ISCN，1985）中的术语。这种重新编码便于使用标准统计软件包进行多变量分析。例如，本文记录了来自11种白血病的714例病例的核型（Mitelman，1983），并对其进行判别分析（SPSSx，1983）。在11种FAB白血病类型中的6种中，明显存在显著的核型特异性。另外4种显示出不显著的特异性水平，而最后一种则不明确。这些结果仅仅证实了目前的观点。然而，通过计算机化多变量分析生成这些结果是新颖的，并证实了该方法的可行性。以这种定量形式，核型数据可以与任何其他具有诊断或预后价值的数据相结合。给定这样一个整合的数据集，可以通过单一程序提取有关肿瘤形成任何方面的所需信息。
