Jones Jennifer, Murphy Craig P, Sleator Roy D, Culligan Eamonn P
Department of Biological Sciences, Munster Technological University, Bishopstown, Cork, T12 P928, Ireland.
Department of Biological Sciences, Munster Technological University, Bishopstown, Cork, T12 P928, Ireland.
Microb Pathog. 2021 Dec;161(Pt B):105295. doi: 10.1016/j.micpath.2021.105295. Epub 2021 Nov 18.
Improvements in bacterial culturing and DNA sequencing techniques have revealed a diverse, and hitherto unknown, urinary tract microbiome (urobiome). The potential role of this microbial community in contributing to health and disease, particularly in the context of urinary tract infections (UTIs) is of significant clinical importance. However, while several studies have confirmed the existence of a core urobiome, the role of its constituent microbes is not yet fully understood, particularly in the context of health and disease. Herein, we review the current state of the art, concluding that the urobiome represents an important component of the body's innate immune defences, and a potentially rich resource for the development of alternative treatment and control strategies for UTIs.
细菌培养和DNA测序技术的改进揭示了一个多样且此前未知的泌尿道微生物群（泌尿微生物群）。这个微生物群落对健康和疾病的潜在作用，尤其是在尿路感染（UTIs）的背景下，具有重大的临床意义。然而，虽然多项研究已证实核心泌尿微生物群的存在，但其组成微生物的作用尚未完全明确，尤其是在健康和疾病方面。在此，我们综述了当前的技术水平，得出结论：泌尿微生物群是人体先天免疫防御的重要组成部分，也是开发UTIs替代治疗和控制策略的潜在丰富资源。
