采用单剂 1.5 克静脉注射阿奇霉素治疗军团菌病：一家三级医院 18 年的经验。
Treatment of legionellosis including a single intravenous dose of 1.5 g azithromycin: 18-year experience at a tertiary care hospital.
机构信息
Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria; Department of Clinical Pharmacology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Department of Neurophysiology, Center for Brain Research, Medical University Vienna, Spitalgasse 4, 1090 Vienna, Austria.
出版信息
Int J Antimicrob Agents. 2022 Jan;59(1):106481. doi: 10.1016/j.ijantimicag.2021.106481. Epub 2021 Nov 18.
OBJECTIVES
Due to recent safety concerns regarding fluoroquinolones and the potential medical and economic benefits, we investigated the efficacy of a single intravenous dose of 1.5 g azithromycin for the treatment of pulmonary legionellosis.
METHODS
Using a nationwide legionellosis registry for pre-selection, 74 patients admitted from 2000-2018 to a tertiary care hospital owing to pneumonia caused by Legionella pneumophila were retrospectively included in this study.
RESULTS
Conventional treatment regimens consisting of fluoroquinolones (n = 20), macrolides (n = 30) or combinations of both (n = 24) and a single intravenous dose of azithromycin (n = 12) have been demonstrated to be equally effective. Single-dose azithromycin treatment was well tolerated and resulted in a shorter hospital stay (P = 0.0464) and shorter antibiotic treatment duration (P = 0.0004) allowing earlier discharge.
CONCLUSION
A single intravenous dose of azithromycin might be a valuable treatment alternative for patients with legionellosis.
目的
由于氟喹诺酮类药物的近期安全性问题以及其潜在的医学和经济效益，我们研究了单次静脉注射 1.5 克阿奇霉素治疗肺部军团菌病的疗效。
方法
本研究使用全国性军团菌病登记处进行预筛选，回顾性纳入了 2000 年至 2018 年期间因肺炎克雷伯菌引起肺炎而入住三级护理医院的 74 名患者。
结果
氟喹诺酮类药物（n=20）、大环内酯类药物（n=30）或两者联合治疗（n=24）以及单次静脉注射阿奇霉素（n=12）的常规治疗方案同样有效。单次阿奇霉素治疗耐受性良好，可缩短住院时间（P=0.0464）和抗生素治疗持续时间（P=0.0004），从而更早出院。
结论
单次静脉注射阿奇霉素可能是军团菌病患者的一种有价值的治疗选择。
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