Turku PET Centre, Turku University Hospital and University of Turku, PO Box 52, FI-20521 Turku, Finland.
Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, FI-20014 Turun yliopisto, Finland.
Conscious Cogn. 2021 Nov;96:103239. doi: 10.1016/j.concog.2021.103239. Epub 2021 Nov 18.
To understand how anesthetics with different molecular mechanisms affect consciousness, we explored subjective experiences recalled after responsive and unresponsive sedation induced with equisedative doses of dexmedetomidine, propofol, sevoflurane, and S-ketamine in healthy male participants (N = 140). The anesthetics were administered in experimental setting using target-controlled infusion or vapouriser for one hour. Interviews conducted after anesthetic administration revealed that 46.9% (n = 46) of arousable participants (n = 98) reported experiences, most frequently dreaming or memory incorporation of the setting. Participants receiving dexmedetomidine reported experiences most often while S-ketamine induced the most multimodal experiences. Responsiveness at the end of anesthetic administration did not affect the prevalence or content of reported experiences. These results demonstrate that subjective experiences during responsive and unresponsive sedation are common and anesthetic agents with different molecular mechanisms of action may have different effects on the prevalence and complexity of the experiences, albeit in the present sample the differences between drugs were minute.
为了了解具有不同分子机制的麻醉剂如何影响意识，我们探索了在健康男性参与者中使用等效剂量的右美托咪定、丙泊酚、七氟醚和 S-氯胺酮诱导有反应性和无反应性镇静后回忆的主观体验（N=140）。在实验环境中使用靶控输注或蒸发器施用麻醉剂一个小时。麻醉后进行的访谈显示，46.9%（n=46）可唤醒的参与者（n=98）报告了体验，最常见的是做梦或对环境的记忆融合。接受右美托咪定的参与者报告体验的频率最高，而 S-氯胺酮则引起最多的多模式体验。麻醉结束时的反应性并不影响报告体验的普遍性或内容。这些结果表明，有反应性和无反应性镇静期间的主观体验很常见，作用机制不同的麻醉剂可能会对体验的普遍性和复杂性产生不同的影响，但在本样本中，药物之间的差异很小。
