Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China.
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Small. 2021 Dec;17(51):e2105439. doi: 10.1002/smll.202105439. Epub 2021 Nov 21.
DNAzyme-nanomaterial bioconjugates are a popular hybrid and have received major attention for diverse biomedical applications, such as bioimaging, biosensor development, cancer therapy, and drug delivery. Therefore, significant efforts are made to develop different strategies for the preparation of inorganic and organic nanoparticles (NPs) with specific morphologies and properties. DNAzymes functionalized with metal-organic frameworks (MOFs), gold nanoparticles (AuNPs), graphene oxide (GO), and molybdenum disulfide (MoS ) are introduced and summarized in detail in this review. Moreover, the focus is on representative examples of applications of DNAzyme-nanomaterials over recent years, especially in bioimaging, biosensing, phototherapy, and stimulation response delivery in living systems, with their several advantages and drawbacks. Finally, the perspective regarding the future directions of research addressing these challenges is also discussed and highlighted.
DNA 酶-纳米材料缀合物是一种流行的杂合体，因其在生物医学应用方面的多样性而受到广泛关注，如生物成像、生物传感器开发、癌症治疗和药物输送。因此，人们做出了巨大的努力来开发不同的策略，以制备具有特定形态和性能的无机和有机纳米粒子（NPs）。在这篇综述中，详细介绍并总结了功能化 DNA 酶的金属有机骨架（MOFs）、金纳米粒子（AuNPs）、氧化石墨烯（GO）和二硫化钼（MoS）。此外，重点介绍了近年来 DNA 酶-纳米材料应用的代表性实例，特别是在生物成像、生物传感、光疗以及活体系统中的刺激反应输送方面，同时讨论了其优缺点。最后，还讨论并强调了针对这些挑战的未来研究方向的观点。
