Cho Ah Young, Roh Jung Gi, Shim Young Suk, Lee Hae Sang, Hwang Jin Soon
Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea.
J Pediatr Endocrinol Metab. 2021 Nov 22;35(1):97-103. doi: 10.1515/jpem-2021-0542. Print 2022 Jan 27.
Children and adolescents with obesity can now be classified according to metabolic profile, as those with metabolically healthy obesity (MHO) and those with metabolically unhealthy obesity (MUO). We aimed to determine the prevalence of MUO and identify its biochemical predictors in pediatric patients with obesity.
We evaluated the medical records of 187 boys and girls with obesity. The children were divided into MHO and MUO groups, and anthropometric and biochemical parameters were assessed. Oral glucose tolerance test (OGTT) was used to identify impaired glucose regulation and hyperinsulinism, and binary logistic regression analysis was used to determine predictors of MUO in children with obesity.
Of the 187 children, MUO was found in 71.7% (n=134) and MHO in 28.3% (n=53); those in the MHO group were younger than those in the MUO group. Blood pressure, triglyceride, total cholesterol, and uric acid levels were significantly higher in the MUO group than in the MHO group. Further, the MUO group exhibited a significantly higher level of insulin resistance (p<0.05) than the MHO group. Serum levels of uric acid and homeostasis model assessment of insulin resistance index (HOMA-IR) were confirmed as biochemical predictors of the MUO phenotype in children with obesity.
The ratio of MUO in children with obesity was relatively high; further, serum levels of uric acid and HOMA-IR can be used as biochemical predictors of MUO.
肥胖的儿童和青少年现在可根据代谢状况进行分类，分为代谢健康型肥胖（MHO）和代谢不健康型肥胖（MUO）。我们旨在确定儿科肥胖患者中MUO的患病率，并识别其生化预测指标。
我们评估了187名肥胖男孩和女孩的病历。将这些儿童分为MHO组和MUO组，并评估人体测量和生化参数。采用口服葡萄糖耐量试验（OGTT）来识别糖调节受损和高胰岛素血症，并使用二元逻辑回归分析来确定肥胖儿童中MUO的预测指标。
在187名儿童中，发现MUO的比例为71.7%（n = 134），MHO的比例为28.3%（n = 53）；MHO组的儿童比MUO组的儿童年龄更小。MUO组的血压、甘油三酯、总胆固醇和尿酸水平显著高于MHO组。此外，MUO组的胰岛素抵抗水平显著高于MHO组（p<0.05）。血清尿酸水平和胰岛素抵抗稳态模型评估指数（HOMA-IR）被确认为肥胖儿童MUO表型的生化预测指标。
肥胖儿童中MUO的比例相对较高；此外，血清尿酸水平和HOMA-IR可作为MUO的生化预测指标。
