Liu Zhiwei, Sun Liang, Li Fengshun, Liu Tengjiao, Yin XingLong, Zhang Jingjing, Sun Nana, Zhang Yulong, Yao Gaofeng, Liu Yun
Department of Psychiatry, The Third People's Hospital of Fuyang, Fuyang, 236015, Anhui, China.
Department of Psychiatry, Fuyang Mental Health Center, Fuyang, 236015, China.
Sci Rep. 2025 Jul 1;15(1):21084. doi: 10.1038/s41598-025-07589-z.
Obesity now stands as a paramount public health challenge globally. The classification of individuals with obesity extends into two categories: those with metabolically healthy obesity (MHO) and those with metabolically unhealthy obesity (MUO), differentiated by the presence or absence of metabolic irregularities. This study aimed to explore the independent correlates of MHO or MUO in children and adolescents with depressive disorders. In a study conducted at the Third People's Hospital of Fuyang throughout 2021, 515 pediatric adolescent in-patient patients diagnosed with depressive disorders according to the ICD-10 criteria were examined. Comprehensive demographic and clinical data were gathered for these individuals. Using regression analysis, the research delved into the distinct impacts of MHO and MUO on these patients. This approach aimed to discern the varying contributions of metabolic health statuses to depressive symptoms in this demographic group. The detection rates of MHO and MUO were 3.7% (19/515) and 8.0% (41/515), respectively. Compared with the MHO group, patients in the MUO group showed older age, older ages of onset and first hospitalization of depressive disorders, higher systolic and diastolic blood pressure, higher levels of TG, TC/HDL, TG/HDL, TyG index and AST, and lower levels of HDL. Binary regression analysis showed that a high level of LDL (OR = 2.76, P = 0.007) was an independent risk factor for MHO, whereas older age at the onset of the disorders (OR = 0.69, P = 0.002) was a protective factor for MHO. In addition, high levels of TC/HDL (OR = 2.66, P = 0.003), TG/HDL (OR = 1.81, P = 0.034), AST (OR = 1.03, P < 0.001), and uric acid (OR = 1.004, P = 0.018) were independent risk factors for MUO. Children and adolescents suffering from depressive disorders exhibit increased rates of both MHO and MUO. It is imperative in clinical settings to monitor these conditions closely. Proactive measures are essential to address the underlying risk factors, thereby mitigating the progression from MHO to MUO and enhancing patient outcomes.
肥胖现已成为全球首要的公共卫生挑战。肥胖个体可分为两类：代谢健康型肥胖（MHO）者和代谢不健康型肥胖（MUO）者，二者的区别在于是否存在代谢异常。本研究旨在探讨患有抑郁症的儿童和青少年中MHO或MUO的独立相关因素。在阜阳市第三人民医院于2021年全年开展的一项研究中，对515名根据ICD - 10标准诊断为抑郁症的儿科青少年住院患者进行了检查。收集了这些个体的全面人口统计学和临床数据。通过回归分析，该研究深入探究了MHO和MUO对这些患者的不同影响。此方法旨在辨别代谢健康状况对该人群抑郁症状的不同影响。MHO和MUO的检出率分别为3.7%（19/515）和8.0%（41/515）。与MHO组相比，MUO组患者年龄更大，抑郁症发病和首次住院年龄更大，收缩压和舒张压更高，TG、TC/HDL、TG/HDL、TyG指数和AST水平更高，HDL水平更低。二元回归分析显示，高水平的LDL（OR = 2.76，P = 0.007）是MHO的独立危险因素，而疾病发病时年龄较大（OR = 0.69，P = 0.002）是MHO的保护因素。此外，高水平的TC/HDL（OR = 2.66，P = 0.003）、TG/HDL（OR = 1.81，P = 0.034）、AST（OR = 1.03，P < 0.001）和尿酸（OR = 1.004，P = 0.018）是MUO的独立危险因素。患有抑郁症的儿童和青少年中MHO和MUO的发生率均有所增加。在临床环境中密切监测这些情况至关重要。采取积极措施来解决潜在危险因素，从而减轻从MHO向MUO的进展并改善患者预后至关重要。
