利用磁共振成像评估慢性炎症性脱髓鞘性多发性神经病下肢肌肉形态的长度依赖性变化。
Length-dependent changes of lower limb muscle morphology in Chronic Inflammatory Demyelinating Polyneuropathy assessed with magnetic resonance imaging.
作者信息
Fanous Jacob, Zero Alexander M, Gilmore Kevin J, Doherty Timothy J, Rice Charles L
机构信息
School of Kinesiology, The University of Western Ontario, London, ON.
Department of Surgery, University of Toronto, Toronto, ON.
出版信息
Eur J Transl Myol. 2021 Nov 18;31(4):10200. doi: 10.4081/ejtm.2021.10200.
The objective of the present study was to assess muscle quantity of the thigh and leg in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) compared to age and sex matched controls in exploring length-dependent changes of innervated muscles. In five people with CIDP and seven controls, magnetic resonance imaging was used to assess muscle morphology of the four parts of the quadriceps and medial hamstring muscles. Findings were compared to the triceps surae from a subset of participants. The CIDP group had less contractile tissue in the quadriceps (11.5%, P<0.05), hamstrings (15.6%, P<0.05) and triceps surae (35.9%, P<0.05) compared to controls. Additionally, CIDP had less contractile tissue (18.7%) in the triceps surae compared to the hamstrings (P<0.05). Muscle quantity in the quadriceps and hamstrings in CIDP was less than controls, but differences were greater for the distal triceps surae. These findings support a length-dependent affect of CIDP on limb musculature composition.
本研究的目的是，在探索受神经支配肌肉的长度依赖性变化时，评估慢性炎症性脱髓鞘性多发性神经病（CIDP）患者与年龄和性别匹配的对照组相比，其大腿和小腿的肌肉量。对5例CIDP患者和7例对照者，采用磁共振成像评估股四头肌和腘绳肌内侧四个部分的肌肉形态。将结果与部分参与者的小腿三头肌进行比较。与对照组相比，CIDP组股四头肌（11.5%，P<0.05）、腘绳肌（15.6%，P<0.05）和小腿三头肌（35.9%，P<0.05）的收缩组织较少。此外，与腘绳肌相比，CIDP患者小腿三头肌的收缩组织较少（18.7%，P<0.05）。CIDP患者股四头肌和腘绳肌的肌肉量少于对照组，但小腿远端三头肌的差异更大。这些发现支持CIDP对肢体肌肉组织组成存在长度依赖性影响。
Zotero 插件