School of Kinesiology, The University of Western Ontario, London, Ontario, Canada.
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.
Muscle Nerve. 2018 Sep;58(3):396-401. doi: 10.1002/mus.26159.
Weakness in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) may be caused by decreases in muscle quantity and quality, but this has not been explored.
Twelve patients with CIDP (mean age 61 years) and 10 age-matched (mean age 59 years) control subjects were assessed for ankle dorsiflexion strength, and two different MRI scans (T1 and T2) of leg musculature.
Isometric strength was 36% lower in CIDP patients compared with controls. Tibialis anterior muscle volumes of CIDP patients were smaller by ∼17% compared with controls, and non-contractile tissue volume was ∼58% greater in CIDP patients. When normalized to total muscle or corrected contractile volume, strength was ∼29% and ∼18% lower, respectively, in CIDP patients.
These results provide insight into the structural integrity of muscle contractile proteins and pathologic changes to whole-muscle tissue composition that contribute to impaired muscle function in CIDP. Muscle Nerve 58: 396-401, 2018.
慢性炎症性脱髓鞘性多发性神经病（CIDP）患者的无力可能是由于肌肉数量和质量的减少引起的，但这一点尚未得到探讨。
对 12 例 CIDP 患者（平均年龄 61 岁）和 10 例年龄匹配的对照者（平均年龄 59 岁）进行踝背屈力量评估，并进行两次不同的腿部肌肉 MRI 扫描（T1 和 T2）。
与对照组相比，CIDP 患者的等长力量低 36%。与对照组相比，CIDP 患者的胫骨前肌体积小 17%左右，非收缩组织体积大 58%左右。当分别归一化为总肌肉或校正的收缩体积时，CIDP 患者的力量分别低 29%和 18%左右。
这些结果深入了解了肌肉收缩蛋白的结构完整性以及整个肌肉组织组成的病理变化，这些变化导致 CIDP 患者肌肉功能受损。肌肉神经 58：396-401，2018 年。
