Pugeat M, Forest M G, de Peretti E, Tourniaire J, Bertrand J
Ann Endocrinol (Paris). 1977;38(6):363-5.
The threshold of sensitivity of the gonadostat has been tested in 20 old menopausal women by clomiphene (50 or 200 mg/day for 5 days) and/or low doses of ethinyl oestradiol (EE2) (10 or 20 microgram/day). Clomiphene did not increase nor decreased serum levels of LH-FSH and testosterone (T) but increased significantly androstenedione (A) levels. Even at the lower dosage used, EE2 decreased drastically the levels of LH but less completely that of FSH. Clomiphene breaks off partially the oestrogen's blockade on FSH but not on LH. No modification was observed for T and A even after 30 days of estrogen therapy. This data shows the peculiar sensitivity of the gonadostat in advanced menopaused women. It also suggests that the gonadostat exhibits a low threshold of sensitivity analogous to that observed in late prepubertal period. Moreover, the different behaviour of LH and FSH in response to the negative feedback of oestrogens supports that an ovarian factor, distinct from estrogens and missing during menopause plays a role in the regulation of FSH.
已通过克罗米芬（50或200毫克/天，共5天）和/或低剂量炔雌醇（EE2）（10或20微克/天）对20名老年绝经后女性的性腺调节素敏感性阈值进行了测试。克罗米芬未升高也未降低血清促黄体生成素-促卵泡生成素（LH-FSH）和睾酮（T）水平，但显著升高了雄烯二酮（A）水平。即使使用较低剂量，EE2也能大幅降低LH水平，但对FSH水平的降低则不太完全。克罗米芬部分解除了雌激素对FSH的阻断，但未解除对LH的阻断。即使在雌激素治疗30天后，T和A也未观察到变化。这些数据显示了性腺调节素在晚期绝经后女性中的特殊敏感性。这也表明性腺调节素表现出与青春期后期观察到的类似的低敏感性阈值。此外，LH和FSH对雌激素负反馈的不同反应支持了一种不同于雌激素且在绝经期间缺失的卵巢因子在FSH调节中起作用。
