• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

生脉散，一种由……组成的传统草药配方，通过抑制大鼠黄嘌呤氧化酶活性和增强尿酸排泄来改善高尿酸血症。 （注：原文中“consisting of”后面内容缺失）

Saengmaeksan, a traditional herbal formulation consisting of , ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats.

作者信息

Sung Yoon-Young, Yuk Heung Joo, Kim Dong-Seon

机构信息

Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.

出版信息

J Ginseng Res. 2021 Sep;45(5):565-574. doi: 10.1016/j.jgr.2021.01.001. Epub 2021 Jan 16.

DOI:10.1016/j.jgr.2021.01.001
PMID:34803426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8587482/
Abstract

BACKGROUND

Saengmaeksan (SMS) is a traditional Korean medicine composed of three herbs, , , and . SMS is used to treat respiratory and cardiovascular disorders. However, whether SMS exerts antihyperuricemic effects is unknown.

METHODS

Effects of the SMS extract in water (SMS-W) and 30% ethanol (SMS-E) were studied in a rat model of potassium oxonate-induced hyperuricemia. Uric acid concentrations and xanthine oxidase (XO) activities were evaluated in the serum, urine, and hepatic tissue. Using renal histopathology to assess kidney function and uric acid excretion, we investigated serum creatinine and blood urea nitrogen concentrations, as well as protein levels of renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), and organic anion transporter 1 (OAT1). The effects of SMS on XO activity and uric acid uptake were also evaluated. The components of SMS were identified using Ultra Performance Liquid Chromatography (UPLC).

RESULTS

SMS-E reduced serum uric acid and creatinine concentrations, and elevated urine uric acid excretion. SMS-E lowered XO activities in both the serum and liver, and downregulated the expression of renal URAT1 and GLUT9 proteins. SMS-E reduced renal inflammation and IL-1β levels in both the serum and kidneys. SMS-E inhibited both XO activity and urate uptake in URAT1-expressing oocytes. Using UPLC, 25 ginsenosides were identified, all of which were present in higher levels in SMS-E than in SMS-W.

CONCLUSION

SMS-E exhibited antihyperuricemic effects by regulating XO activity and renal urate transporters, providing the first evidence of its applicability in the treatment of hyperuricemia and gout.

摘要

背景

生脉散（SMS）是一种由三种草药组成的韩国传统医学方剂。SMS用于治疗呼吸道和心血管疾病。然而，SMS是否具有抗高尿酸血症作用尚不清楚。

方法

在氧嗪酸钾诱导的高尿酸血症大鼠模型中研究了水提取物（SMS-W）和30%乙醇提取物（SMS-E）的作用。评估血清、尿液和肝组织中的尿酸浓度和黄嘌呤氧化酶（XO）活性。通过肾脏组织病理学评估肾功能和尿酸排泄，我们研究了血清肌酐和血尿素氮浓度，以及肾脏尿酸转运蛋白1（URAT1）、葡萄糖转运蛋白9（GLUT9）和有机阴离子转运蛋白1（OAT1）的蛋白水平。还评估了SMS对XO活性和尿酸摄取的影响。使用超高效液相色谱（UPLC）鉴定SMS的成分。

结果

SMS-E降低了血清尿酸和肌酐浓度，并增加了尿尿酸排泄。SMS-E降低了血清和肝脏中的XO活性，并下调了肾脏URAT1和GLUT9蛋白的表达。SMS-E减轻了肾脏炎症以及血清和肾脏中的IL-1β水平。SMS-E抑制了表达URAT1的卵母细胞中的XO活性和尿酸摄取。使用UPLC鉴定出25种人参皂苷，所有这些人参皂苷在SMS-E中的含量均高于SMS-W。

结论

SMS-E通过调节XO活性和肾脏尿酸转运蛋白表现出抗高尿酸血症作用，为其在高尿酸血症和痛风治疗中的适用性提供了首个证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ad8ece8ba4d6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/00fa51934e9c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/5c18bced3289/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ee07c01c31e7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/368dbb0575d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/1fd718e77855/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ddf3888aa6a6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ad8ece8ba4d6/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/00fa51934e9c/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/5c18bced3289/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ee07c01c31e7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/368dbb0575d5/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/1fd718e77855/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ddf3888aa6a6/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a0e/8587482/ad8ece8ba4d6/gr6.jpg

相似文献

1
Saengmaeksan, a traditional herbal formulation consisting of , ameliorates hyperuricemia by inhibiting xanthine oxidase activity and enhancing urate excretion in rats.生脉散，一种由……组成的传统草药配方，通过抑制大鼠黄嘌呤氧化酶活性和增强尿酸排泄来改善高尿酸血症。 （注：原文中“consisting of”后面内容缺失）
J Ginseng Res. 2021 Sep;45(5):565-574. doi: 10.1016/j.jgr.2021.01.001. Epub 2021 Jan 16.
2
Paeonia × suffruticosa Andrews leaf extract and its main component apigenin 7-O-glucoside ameliorate hyperuricemia by inhibiting xanthine oxidase activity and regulating renal urate transporters.牡丹（芍药属）× 藤本植物安德鲁斯提取物及其主要成分芹菜素 7-O-葡萄糖苷通过抑制黄嘌呤氧化酶活性和调节肾脏尿酸转运体来改善高尿酸血症。
Phytomedicine. 2023 Sep;118:154957. doi: 10.1016/j.phymed.2023.154957. Epub 2023 Jul 11.
3
Eggshell Membrane Ameliorates Hyperuricemia by Increasing Urate Excretion in Potassium Oxonate-Injected Rats.蛋壳膜通过增加黄嘌呤氧化酶注射大鼠的尿酸排泄来改善高尿酸血症。
Nutrients. 2021 Sep 23;13(10):3323. doi: 10.3390/nu13103323.
4
Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney.益智仁提取物通过增强肾脏尿酸排泄发挥抗高尿酸血症作用。
Phytomedicine. 2019 Sep;62:152975. doi: 10.1016/j.phymed.2019.152975. Epub 2019 May 31.
5
Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase.黄芩素通过促进尿酸排泄和抑制黄嘌呤氧化酶来缓解高尿酸血症。
Phytomedicine. 2021 Jan;80:153374. doi: 10.1016/j.phymed.2020.153374. Epub 2020 Oct 9.
6
DKB114, A Mixture of Linne Flower and (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion.DKB114，一种由黄花倒水莲和（L.）J. Presl 树皮提取物组成的混合物，通过抑制黄嘌呤氧化酶活性和增加尿液排泄来改善高尿酸血症。
Nutrients. 2018 Sep 28;10(10):1381. doi: 10.3390/nu10101381.
7
Xanthine oxidase inhibitory activity and antihyperuricemic effect of Moringa oleifera Lam. leaf hydrolysate rich in phenolics and peptides.富含酚类和肽的辣木叶水解物的黄嘌呤氧化酶抑制活性和降尿酸作用。
J Ethnopharmacol. 2021 Apr 24;270:113808. doi: 10.1016/j.jep.2021.113808. Epub 2021 Jan 12.
8
Siwu decoction attenuates oxonate-induced hyperuricemia and kidney inflammation in mice.四物汤可减轻氧嗪酸钾诱导的小鼠高尿酸血症和肾脏炎症。
Chin J Nat Med. 2016 Jul;14(7):499-507. doi: 10.1016/S1875-5364(16)30059-0.
9
Extracts of (Burm.f.) Nees Leaves Exert Anti-Gout Effects by Lowering Uric Acid Levels and Reducing Monosodium Urate Crystal-Induced Inflammation.（缅甸）腺背蓝叶提取物通过降低尿酸水平和减轻尿酸钠晶体诱导的炎症发挥抗痛风作用。
Front Pharmacol. 2022 Jan 10;12:787125. doi: 10.3389/fphar.2021.787125. eCollection 2021.
10
Simiao San alleviates hyperuricemia and kidney inflammation by inhibiting NLRP3 inflammasome and JAK2/STAT3 signaling in hyperuricemia mice.四妙散通过抑制高尿酸血症小鼠中的 NLRP3 炎性小体和 JAK2/STAT3 信号通路来缓解高尿酸血症和肾脏炎症。
J Ethnopharmacol. 2023 Aug 10;312:116530. doi: 10.1016/j.jep.2023.116530. Epub 2023 Apr 23.

引用本文的文献

1
Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation.改良三麦散，一种含有六种草药的中药配方，通过RhoA/Rho激酶介导的血管舒张作用改善高血压。
Integr Med Res. 2025 Dec;14(4):101207. doi: 10.1016/j.imr.2025.101207. Epub 2025 Jul 26.
2
Anti-hyperuricemia effect of Clerodendranthus spicatus: a molecular biology study combined with metabolomics.筋骨草属植物的降尿酸作用：结合代谢组学的分子生物学研究。
Sci Rep. 2024 Jul 4;14(1):15449. doi: 10.1038/s41598-024-66454-7.
3
Hesperitin-Copper(II) Complex Regulates the NLRP3 Pathway and Attenuates Hyperuricemia and Renal Inflammation.

本文引用的文献

1
Effect of Stem Extract on Uric Acid Excretion in Hyperuricemia Mice.茎提取物对高尿酸血症小鼠尿酸排泄的影响。
Front Pharmacol. 2019 Dec 10;10:1464. doi: 10.3389/fphar.2019.01464. eCollection 2019.
2
Protective Effect of Panaxynol Isolated from against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies.从三七中分离得到的人参炔醇对顺铂诱导的肾损伤的保护作用：体外和体内研究。
Biomolecules. 2019 Dec 17;9(12):890. doi: 10.3390/biom9120890.
3
The Effects of Ginsenosides and Anserine on the Up-Regulation of Renal Aquaporins 1-4 in Hyperuricemic Mice.
橙皮素-铜（II）复合物调节NLRP3通路并减轻高尿酸血症和肾脏炎症。
Foods. 2024 Feb 15;13(4):591. doi: 10.3390/foods13040591.
4
Comparative Assessment of In Vitro Xanthine Oxidase and α-Glucosidase Inhibitory Activities of Cultured Cambial Meristematic Cells, Adventitious Roots, and Field-Cultivated Ginseng.培养的形成层细胞、不定根和田间种植人参的体外黄嘌呤氧化酶和α-葡萄糖苷酶抑制活性的比较评估。
Nutrients. 2024 Feb 2;16(3):443. doi: 10.3390/nu16030443.
5
Saengmaeksan, a traditional polyherbal formulation containing Panax ginseng, improves energy metabolism during exercise.三芪养生胶囊，一种含有人参的传统复方草药制剂，可改善运动期间的能量代谢。
PLoS One. 2024 Jan 29;19(1):e0296487. doi: 10.1371/journal.pone.0296487. eCollection 2024.
6
Effect of on Fatigue, Liver Function, and Immunity Combined with High-Intensity Training.高强度训练结合对疲劳、肝功能和免疫的影响。
J Immunol Res. 2023 Jun 30;2023:3269293. doi: 10.1155/2023/3269293. eCollection 2023.
7
Combination of C. A. Mey and Febuxostat Boasted Cardioprotective Effects Against Doxorubicin-Induced Acute Cardiotoxicity in Rats.C. A. Mey与非布司他联合用药对阿霉素诱导的大鼠急性心脏毒性具有心脏保护作用。
Front Pharmacol. 2022 Jun 22;13:905828. doi: 10.3389/fphar.2022.905828. eCollection 2022.
8
Tongbixiao Pills Improve Gout by Reducing Uric Acid Levels and Inhibiting Inflammation.通痹消丸通过降低尿酸水平和抑制炎症来改善痛风。
Dose Response. 2022 Apr 9;20(2):15593258221090340. doi: 10.1177/15593258221090340. eCollection 2022 Apr-Jun.
Ginsenosides 和鹅肌肽对高尿酸血症小鼠肾脏水通道蛋白 1-4 上调的影响。
Am J Chin Med. 2019;47(5):1133-1147. doi: 10.1142/S0192415X19500587. Epub 2019 Jul 17.
4
Schisandra fruits for the management of drug-induced liver injury in China: A review.五味子治疗中国药物性肝损伤的研究进展：综述
Phytomedicine. 2019 Jun;59:152760. doi: 10.1016/j.phymed.2018.11.020. Epub 2018 Nov 19.
5
Hyperuricemia and Cardiovascular Disease.高尿酸血症与心血管疾病
Curr Pharm Des. 2019;25(6):700-709. doi: 10.2174/1381612825666190408122557.
6
Safety and tolerability of available urate-lowering drugs: a critical review.降尿酸药物的安全性和耐受性：一项关键性评价。
Expert Opin Drug Saf. 2019 Apr;18(4):261-271. doi: 10.1080/14740338.2019.1594771. Epub 2019 Mar 27.
7
DKB114, A Mixture of Linne Flower and (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion.DKB114，一种由黄花倒水莲和（L.）J. Presl 树皮提取物组成的混合物，通过抑制黄嘌呤氧化酶活性和增加尿液排泄来改善高尿酸血症。
Nutrients. 2018 Sep 28;10(10):1381. doi: 10.3390/nu10101381.
8
Physiology of Hyperuricemia and Urate-Lowering Treatments.高尿酸血症的生理学及降尿酸治疗
Front Med (Lausanne). 2018 May 31;5:160. doi: 10.3389/fmed.2018.00160. eCollection 2018.
9
Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice.芒果苷元衍生物J99745通过抑制小鼠黄嘌呤氧化酶活性和尿酸盐转运蛋白1表达发挥抗高尿酸血症作用。
Acta Pharm Sin B. 2018 Mar;8(2):306-315. doi: 10.1016/j.apsb.2017.05.004. Epub 2017 Jul 29.
10
Improvement of Cisplatin-induced renal dysfunction by Schisandra chinensis stems via anti-inflammation and anti-apoptosis effects.五味子茎通过抗炎和抗细胞凋亡作用改善顺铂诱导的肾功能障碍。
J Ethnopharmacol. 2018 May 10;217:228-237. doi: 10.1016/j.jep.2018.01.033. Epub 2018 Feb 6.