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新冠疫苗接种后出现未确诊的多发性硬化症的罕见病例

A rare presentation of undiagnosed multiple sclerosis after the COVID-19 vaccine.

作者信息

Tagliaferri Ariana R, Horani George, Stephens Katherine, Michael Patrick

机构信息

Department of Internal Medicine, St. Joseph's Hospital, Paterson, NJ, USA.

出版信息

J Community Hosp Intern Med Perspect. 2021 Nov 15;11(6):772-775. doi: 10.1080/20009666.2021.1979745. eCollection 2021.

Abstract

Multiple sclerosis (MS) is an auto-immune mediated neurological disorder that affects the central nervous system and leads to myelin sheath destruction. The pathogenesis of MS involves T helper cells causing inflammation and eventual death of the oligodendrocytes. Etiologies for the development of MS include a combination of genetic, environmental, and immune factors. Vaccines have been proposed to increase the immune response and have reportedly activated some autoimmune disorders. Although certain vaccines such as hepatitis B have been associated with MS, studies have refuted these cases. We present a rare case of a 32-year-old patient who presented with symptoms and suggestive of MS a few days after receiving the COVID vaccine. Laboratory and imaging findings confirmed the diagnosis of MS, and she was started on steroids and discharged in a stable condition a few days after.

摘要

多发性硬化症(MS)是一种自身免疫介导的神经系统疾病,会影响中枢神经系统并导致髓鞘破坏。MS的发病机制涉及辅助性T细胞引发炎症并最终导致少突胶质细胞死亡。MS发病的病因包括遗传、环境和免疫因素的综合作用。有人提出疫苗会增强免疫反应,据报道还会引发一些自身免疫性疾病。尽管某些疫苗如乙肝疫苗与MS有关,但研究已反驳了这些病例。我们报告一例罕见病例,一名32岁患者在接种新冠疫苗几天后出现提示MS的症状。实验室和影像学检查结果确诊为MS,她开始接受类固醇治疗,几天后病情稳定出院。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01db/8604537/f4219025235d/ZJCH_A_1979745_F0001_OC.jpg

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