Rodriguez Thalia, Dobrovolny Hana M
Department of Physics and Astronomy, Texas Christian University, Fort Worth, TX, USA.
R Soc Open Sci. 2021 Nov 17;8(11):202345. doi: 10.1098/rsos.202345. eCollection 2021 Nov.
The SARS-CoV-2 virus disproportionately causes serious illness and death in older individuals. In order to have the greatest impact in decreasing the human toll caused by the virus, antiviral treatment should be targeted to older patients. For this, we need a better understanding of the differences in viral dynamics between SARS-CoV-2 infection in younger and older adults. In this study, we use previously published averaged viral titre measurements from the nose and throat of SARS-CoV-2 infection in young and aged cynomolgus macaques to parametrize a viral kinetics model. We find that all viral kinetics parameters differ between young and aged macaques in the nasal passages, but that there are fewer differences in parameter estimates from the throat. We further use our parametrized model to study the antiviral treatment of young and aged animals, finding that early antiviral treatment is more likely to lead to a lengthening of the infection in aged animals, but not in young animals.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒在老年人中更容易引发严重疾病和死亡。为了在降低该病毒造成的人员伤亡方面产生最大影响，抗病毒治疗应针对老年患者。为此，我们需要更好地了解年轻人和老年人感染SARS-CoV-2病毒后病毒动力学的差异。在本研究中，我们使用先前发表的年轻和老年食蟹猕猴感染SARS-CoV-2病毒后鼻腔和咽喉的平均病毒滴度测量值，对病毒动力学模型进行参数化。我们发现，年轻和老年猕猴鼻腔中的所有病毒动力学参数均存在差异，但咽喉的参数估计差异较少。我们进一步使用参数化模型研究年轻和老年动物的抗病毒治疗，发现早期抗病毒治疗更有可能导致老年动物感染时间延长，但对年轻动物则不然。
