Saeed Zeshan K, Fisher Kerry, Melath Sunil, Omar Bushra
Rheumatology, Frimley Park Hospital, Frimley, GBR.
Rheumatology, Royal Berkshire Hospital, Reading, GBR.
Cureus. 2021 Nov 12;13(11):e19511. doi: 10.7759/cureus.19511. eCollection 2021 Nov.
A previously independent 83-year-old lady presents with acute confusion, decreased mobility, urinary retention, and constipation, having recently received a course of oral acyclovir for shingles. The patient was noted to have extensive bruising to her upper limbs, and blood tests showed raised inflammatory markers with low platelet count, although this remained above 75 × 10/L. Her confusion on a background of shingles raised the differential diagnosis of varicella-zoster virus (VZV) encephalitis. CT head and MRI brain showed no acute intracranial abnormality. Lumbar puncture yielded frankly haemorrhagic cerebrospinal fluid (CSF), but viral polymerase chain reaction (PCR) testing was negative for the varicella-zoster virus. She later developed further right shoulder pain and right lower limb weakness three days post-initial lumbar puncture. Repeat CT head was unremarkable. MRI spine showed extensive spinal subarachnoid haemorrhage, with possible cervical arteriovenous malformation and L5/S1 spinal nerve compression. The patient was managed conservatively with dexamethasone and inpatient physiotherapy support. She was discharged after a long hospital stay at a new mobility baseline requiring hoist transfers.
一位83岁、此前生活自理的女士出现急性意识模糊、活动能力下降、尿潴留和便秘症状,她近期因带状疱疹接受了一个疗程的口服阿昔洛韦治疗。患者上肢有大面积瘀伤,血液检查显示炎症指标升高且血小板计数偏低,不过仍高于75×10⁹/L。她在带状疱疹背景下出现意识模糊,这增加了水痘-带状疱疹病毒(VZV)脑炎的鉴别诊断可能性。头颅CT和脑部MRI未显示急性颅内异常。腰椎穿刺获取的脑脊液呈明显血性,但水痘-带状疱疹病毒的病毒聚合酶链反应(PCR)检测为阴性。初次腰椎穿刺三天后,她后来又出现右肩部疼痛加剧和右下肢无力症状。复查头颅CT无异常。脊柱MRI显示广泛的脊髓蛛网膜下腔出血,可能存在颈动静脉畸形和L5/S1脊神经受压情况。患者接受了地塞米松保守治疗和住院物理治疗支持。经过长时间住院后,她以新的活动能力基线出院,需要借助升降机转移。