硫辛酸代谢作为针对[具体疾病名称1]和[具体疾病名称2]的潜在化疗靶点。 需注意，你提供的原文中“and.”后面缺少具体内容，我按照常规补充了疾病名称示例以便完整呈现译文意思，你可根据实际情况修改完善。
Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against and .
作者信息
Rei Yan Sun Liu, Wakasuqui Felipe, Du Xiaochen, Groves Matthew R, Wrenger Carsten
机构信息
Unit for Drug Discovery, Department of Parasitology, Institute of Biomedical Sciences-ICB, University of São Paulo, São Paulo, Brazil.
Structural Biology in Drug Design, Department of Drug Design, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
出版信息
Front Chem. 2021 Nov 4;9:742175. doi: 10.3389/fchem.2021.742175. eCollection 2021.
Lipoic acid (LA) is an organic compound that plays a key role in cellular metabolism. It participates in a posttranslational modification (PTM) named lipoylation, an event that is highly conserved and that occurs in multimeric metabolic enzymes of very distinct microorganisms such as and , including pyruvate dehydrogenase (PDH) and -ketoglutarate dehydrogenase (KDH). In this mini review, we revisit the recent literature regarding LA metabolism in and , by covering the lipoate ligase proteins in both microorganisms, the role of lipoate ligase proteins and insights for possible inhibitors of lipoate ligases.
硫辛酸（LA）是一种在细胞代谢中起关键作用的有机化合物。它参与一种名为硫辛酰化的翻译后修饰（PTM），这一过程高度保守，发生在诸如[具体微生物1]和[具体微生物2]等非常不同的微生物的多聚体代谢酶中，包括丙酮酸脱氢酶（PDH）和α-酮戊二酸脱氢酶（KDH）。在本综述中，我们通过涵盖这两种微生物中的硫辛酸连接酶蛋白、硫辛酸连接酶蛋白的作用以及硫辛酸连接酶可能的抑制剂的相关见解，重新审视了关于[具体微生物1]和[具体微生物2]中硫辛酸代谢的最新文献。
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