Meroterpenoids From Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer.

fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (-), were characterized from Their structures were identified using spectroscopic and computational methods. Structurally, compound features a novel dioxabicyclo[2.2.2]octan-3-one motif in the side chain. Ethnoknowledge-derived biological evaluation found that (+)- could activate Akt and AMPK phosphorylation in insulin-stimulated C2C12 cells, and (+)- could activate glucose uptake dose dependently in C2C12 cells. Furthermore, we found that (+)- (+)-, and (-)- could significantly inhibit cell migration of the MDA-MB-231 cell line, of which (+)- showed significant inhibitory effects against cell migration of the MDA-MB-231 cell line in a dose-dependent manner. These findings revealed the meroterpenoidal composition of and its roles in the prevention of chronic diseases such as diabetes mellitus and triple-negative breast cancer.