Cardellicchio Pasquale, Dolfini Elisa, D'Ausilio Alessandro
IIT@UniFe Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Via Fossato di Mortara, 17-19, 44121 Ferrara, Italy.
Department of Neuroscience and Rehabilitation, Section of Physiology, Università di Ferrara, Via Fossato di Mortara, 17-19, 44121 Ferrara, Italy.
iScience. 2021 Oct 23;24(11):103330. doi: 10.1016/j.isci.2021.103330. eCollection 2021 Nov 19.
Human sensorimotor interaction requires mutual behavioral adaptation as well as shared cognitive task representations (Joint Action, JA). Yet, an under-investigated aspect of JA is the neurobehavioral mechanisms employed to stop actions if the context calls for it. Sparse evidence points to the possible contribution of the left dorsal premotor cortex (lPMd) in sculpting movements according to the socio-interactive context. To clarify this issue, we ran two experiments integrating a classical stop signal paradigm with an ecological JA task. The first behavioral study shows longer Stop performance in the JA condition. In the second, we use transcranial magnetic stimulation to inhibit the lPMd or a control site (vertex). Results show that lPMd modulates the JA stopping performance. Action stopping is an important component of JA coordination, and here we provide evidence that lPMd is a key node of a brain network recruited for online mutual co-adaptation in social contexts.
人类的感觉运动交互需要相互的行为适应以及共享的认知任务表征（联合行动，JA）。然而，联合行动中一个研究不足的方面是，在情境需要时用于停止动作的神经行为机制。稀少的证据表明，左背侧运动前区皮质（lPMd）可能在根据社会交互情境塑造动作方面发挥作用。为了阐明这个问题，我们进行了两项实验，将经典的停止信号范式与生态联合行动任务相结合。第一项行为研究表明，在联合行动条件下停止动作的表现时间更长。在第二项实验中，我们使用经颅磁刺激来抑制lPMd或一个对照部位（头顶）。结果表明，lPMd调节联合行动中的停止动作表现。动作停止是联合行动协调的一个重要组成部分，在此我们提供证据表明，lPMd是在社会情境中为在线相互共同适应而招募的脑网络的一个关键节点。
