Zhang Guodong, Wang Maoqiang, Duan Feng, Yuan Kai, Yan Jieyu, Chang Zhongfei
Department of Interventional Radiology, Chinese PLA General Hospital, 28# Fuxing RD, Beijing 100853, China.
Department of Interventional Radiology, Shandong medical imaging research institute, Shandong University, 324# Jingwu Rd, Jinan 250021, China.
J Interv Med. 2019 Apr 30;1(2):86-91. doi: 10.19779/j.cnki.2096-3602.2018.02.05. eCollection 2018 May.
To evaluate the early- and intermediate-term outcome in patients with symptomatic hepatic focal nodular hyperplasia (FNH) treated with transarterial embolization using bleomycin-iodinated oil and polyvinyl alcohol (PVA) particles. In this two-center retrospective study between January 2005 and December 2013, 27 consecutive patients with symptomatic hepatic FNH underwent superselective catheterization by microcatheter techniques and embolization using bleomycin-iodinated oil combined with PVA. Early-term (3-41 months) follow-up of TAE was performed in terms of symptom control, changes in lesion size, and complications. Intermediate-term (45-112 months) follow-up was carried out to assess symptom control and reinterventions for recurrence. Embolization was performed in 27 patients with 31 lesions. Technical success was achieved in all cases. The follow-up period ranged from three to 112 months. At early-term follow-up, mean lesion diameters were decreased significantly from 6.4±2.7 cm pre-intervention to 3.6±1.8 cm at 3-9 months after embolization (). A total of 7 lesions had complete resolution during the whole follow-up period. At intermediate-term follow-up, local recurrence was found in 1 treated lesion at 54-months. Contrast-enhanced scans showed complete lack of residual arterial blood supply in the majority of lesions during the follow-up period. There was no major complication associated with the procedure. Transarterial embolization using bleomycin-iodinated oil and PVA is a feasible, safe and effective alternative in both early- and intermediate-terms for the treatment of symptomatic hepatic FNH.
评估使用博来霉素-碘化油和聚乙烯醇（PVA）颗粒经动脉栓塞治疗有症状的肝局灶性结节性增生（FNH）患者的早期和中期结局。在这项2005年1月至2013年12月的双中心回顾性研究中，27例连续的有症状的肝FNH患者通过微导管技术进行了超选择性导管插入术，并使用博来霉素-碘化油联合PVA进行栓塞。对TAE进行了早期（3 - 41个月）随访，包括症状控制、病变大小变化和并发症。进行了中期（45 - 112个月）随访以评估症状控制和复发的再次干预情况。对27例患者的31个病变进行了栓塞。所有病例均取得技术成功。随访期为3至112个月。在早期随访时，平均病变直径从干预前的6.4±2.7 cm显著减小至栓塞后3 - 9个月时的3.6±1.8 cm（）。在整个随访期间，共有7个病变完全消退。在中期随访时，1个治疗病变在54个月时出现局部复发。对比增强扫描显示在随访期间大多数病变完全缺乏残余动脉血供。该手术未发生重大并发症。使用博来霉素-碘化油和PVA进行经动脉栓塞在治疗有症状的肝FNH的早期和中期都是一种可行、安全且有效的替代方法。
