Montanaro N, Dall'Olio R, Gandolfi O
Neuropsychobiology. 1979;5(3):174-80. doi: 10.1159/000117680.
Bromolysergide (BOL 148) and methysergide (UML 491), 2 mg/kg intraperitoneally, and saline were administered to rats 45 min before one-trial passive-avoidance conditioning followed by electroconvulsive shock (ECS) or sham-ECS (ECS). On test session (24 h later), the groups treated with both BOL 148 and UML 491 exhibited a clear-cut retention in comparison to saline-ECS rats. On the other hand, all drugged groups, regardless of their submission to ECS, showed a little less pronounced consolidation than saline-ECS rats. The antiamnestic effect brought about by the two drugs was discussed in terms of receptor antagonism against ECS-released brain serotonin, whereas the lower passive-avoidance level observed in treated animals was considered in relation to a possible antipunishment effect of antiserotoninergic treatment.
在单次被动回避条件反射并接受电休克（ECS）或假电休克（sham - ECS）前45分钟，给大鼠腹腔注射2毫克/千克的溴麦角环肽（BOL 148）、甲基麦角新碱（UML 491）和生理盐水。在测试阶段（24小时后），与生理盐水 - ECS组大鼠相比，接受BOL 148和UML 491治疗的组表现出明显的记忆保留。另一方面，所有用药组，无论是否接受ECS，与生理盐水 - ECS组大鼠相比，巩固作用都稍弱。从对ECS释放的脑5-羟色胺的受体拮抗作用方面讨论了这两种药物产生的抗遗忘作用，而在接受治疗的动物中观察到的较低被动回避水平则被认为与抗5-羟色胺能治疗可能的抗惩罚作用有关。
