Kamath S, Andrade C, Faruqi S, Venkataraman B V, Naga Rani M A, Candade V S
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Convuls Ther. 1997 Sep;13(3):185-95.
Two once-daily electroconvulsive shocks (ECS) produced retrograde amnesia in rats trained on a Hebb-Williams maze; Verapamil (12.5 mg/kg, i.p.) or felodipine (10 mg/kg, p.o.) administered half an hour before each ECS attenuated this ECS-induced amnesia. Hence, these drugs may hold promise for the containment of amnesia induced by electroconvulsive therapy (ECT). Speculatively, one or more of several mechanisms may be involved: cerebral vasodilatation, enhancement of cholinergic tone, and inhibition of calcium-mediated impairment of neuronal function. These drugs may also act by attenuating the systolic surge in blood pressure during ECT, thereby decreasing edema due to cerebral hyperperfusion, as well as decreasing the possible transfer of potentially neurotoxic macromolecules through a putative breach in the blood-brain barrier.
每天一次给予大鼠两次电惊厥休克（ECS）会使其在赫布 - 威廉姆斯迷宫训练中出现逆行性遗忘；在每次ECS前半小时腹腔注射维拉帕米（12.5毫克/千克）或口服非洛地平（10毫克/千克）可减轻这种由ECS诱导的遗忘。因此，这些药物可能有望用于控制电惊厥治疗（ECT）引起的遗忘。据推测，可能涉及几种机制中的一种或多种：脑血管舒张、胆碱能张力增强以及抑制钙介导的神经元功能损伤。这些药物还可能通过减弱ECT期间的收缩期血压波动起作用，从而减少因脑过度灌注引起的水肿，以及减少潜在神经毒性大分子可能通过推测的血脑屏障破损处的转运。
