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用易于获取的柯萨奇病毒 B3 完整动力学计算模型模拟其感染。

Simulating coxsackievirus B3 infection with an accessible computational model of its complete kinetics.

机构信息

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.

出版信息

STAR Protoc. 2021 Nov 5;2(4):100940. doi: 10.1016/j.xpro.2021.100940. eCollection 2021 Dec 17.

DOI:10.1016/j.xpro.2021.100940
PMID:34806049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8585652/
Abstract

We describe how to use a publicly available computational model for coxsackievirus B3 (CVB3) infection that we recast as a graphical user interface (GUI). The GUI-based implementation enables non-computationalists to incorporate systems-biology modeling into their research and teaching. The model simulates the full life cycle of CVB3, including the host antiviral response, and includes 44 alterable parameters. The model simplifies some viral life cycle processes to improve interpretability and utility when performing experiments. For complete details on the use and execution of this protocol, please refer to Lopacinski et al. (2021).

摘要

我们描述了如何使用我们重新构建为图形用户界面 (GUI) 的公开可用的柯萨奇病毒 B3 (CVB3) 感染计算模型。基于 GUI 的实现使非计算机科学家能够将系统生物学建模纳入他们的研究和教学中。该模型模拟了 CVB3 的完整生命周期，包括宿主抗病毒反应，并且包含 44 个可改变的参数。该模型简化了一些病毒生命周期过程，以提高在进行实验时的可解释性和实用性。有关使用和执行此方案的完整详细信息，请参阅 Lopacinski 等人。(2021)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/b85807ab3ce2/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/6adac495a0e7/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/cb855e3b6dc9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/8cb64b76b466/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/662f1a9959ca/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/96565e3644c6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/176b7a8b6791/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/2e8c838a7e2d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/fc1f684a4852/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/fac004be0cd2/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/f5a67bb4e8de/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/b85807ab3ce2/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/6adac495a0e7/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/cb855e3b6dc9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/8cb64b76b466/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/662f1a9959ca/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/96565e3644c6/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/176b7a8b6791/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/2e8c838a7e2d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/fc1f684a4852/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/fac004be0cd2/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/f5a67bb4e8de/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/8585652/b85807ab3ce2/gr10.jpg

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Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures.多种中间结构揭示了 RNA 依赖性 RNA 聚合酶易位的严格控制。
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