Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, 710127, China.
Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, 710069, China.
ChemMedChem. 2022 Jan 19;17(2):e202100656. doi: 10.1002/cmdc.202100656. Epub 2021 Dec 4.
Magnetic hyperthermia (MHT) uses magnetic iron oxide nanoparticles (MIONs) to irradiate heat when subjected to an alternating magnetic field (AMF), which then trigger a series of biological effects to realize rapid tumor-killing effects. With the deepening in research, MHT has also shown significant potential in achieving antitumor immunity. On the other hand, immunotherapy in cancer treatment has gained increasing attention over recent years and excellent results have generally been reported. Using MHT to activate antitumor immunity and clarifying its synergistic mechanism, i. e., immunogenic cell death (ICD) and immunosuppressive tumor microenvironment (TME) reversal, can achieve a synergistically enhanced therapeutic effect on primary tumors and metastatic lesions, and this can prevent cancer recurrence and metastasis, which thus prolong survival. In this review, we discussed the role of MHT when utilized alone and combining MHT with other treatments (such as radiotherapy, photodynamic therapy, and immune checkpoint blockers) in the process of tumor immunotherapy, including antigen release, dendritic cells (DCs) maturation, and activation of CD8 cytotoxic T lymphocytes. Finally, the challenges and future development of current MHT and immunotherapy are discussed.
磁热疗（MHT）利用磁性氧化铁纳米粒子（MIONs）在交变磁场（AMF）下产生热量，从而引发一系列生物效应，实现快速的肿瘤杀伤效果。随着研究的深入，MHT 在实现抗肿瘤免疫方面也显示出了显著的潜力。另一方面，癌症治疗中的免疫疗法近年来受到了越来越多的关注，并且通常报告了优异的结果。使用 MHT 激活抗肿瘤免疫并阐明其协同机制，即免疫原性细胞死亡（ICD）和免疫抑制性肿瘤微环境（TME）逆转，可以对原发性肿瘤和转移性病变产生协同增强的治疗效果，从而预防癌症复发和转移，从而延长生存时间。在这篇综述中，我们讨论了 MHT 在肿瘤免疫治疗过程中单独使用和与其他治疗方法（如放射治疗、光动力疗法和免疫检查点抑制剂）联合使用时的作用，包括抗原释放、树突状细胞（DCs）成熟和 CD8 细胞毒性 T 淋巴细胞的激活。最后，讨论了当前 MHT 和免疫疗法的挑战和未来发展。
