Department of Radiation Oncology, Division of Thoracic Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
College of Management, Sichuan Agricultural University, Chengdu, China.
Front Immunol. 2023 Oct 6;14:1258786. doi: 10.3389/fimmu.2023.1258786. eCollection 2023.
In the quest for cancer treatment modalities with greater effectiveness, the combination of tumor immunotherapy and nanoparticle-based hyperthermia has emerged as a promising frontier. The present article provides a comprehensive review of recent advances and cutting-edge research in this burgeoning field and examines how these two treatment strategies can be effectively integrated. Tumor immunotherapy, which harnesses the immune system to recognize and attack cancer cells, has shown considerable promise. Concurrently, nanoparticle-based hyperthermia, which utilizes nanotechnology to promote selective cell death by raising the temperature of tumor cells, has emerged as an innovative therapeutic approach. While both strategies have individually shown potential, combination of the two modalities may amplify anti-tumor responses, with improved outcomes and reduced side effects. Key studies illustrating the synergistic effects of these two approaches are highlighted, and current challenges and future prospects in the field are discussed. As we stand on the precipice of a new era in cancer treatment, this review underscores the importance of continued research and collaboration in bringing these innovative treatments from the bench to the bedside.
在寻求更有效的癌症治疗方法的过程中，肿瘤免疫疗法和基于纳米粒子的热疗的结合已经成为一个有前途的领域。本文全面回顾了这一新兴领域的最新进展和前沿研究，并探讨了如何有效地整合这两种治疗策略。肿瘤免疫疗法利用免疫系统识别和攻击癌细胞，已经显示出相当大的潜力。同时，基于纳米粒子的热疗利用纳米技术通过提高肿瘤细胞的温度来促进选择性细胞死亡，已经成为一种创新的治疗方法。虽然这两种策略都具有潜在的作用，但将这两种方法结合起来可能会增强抗肿瘤反应，改善治疗效果并减少副作用。本文重点介绍了这些方法协同作用的关键研究，并讨论了该领域当前的挑战和未来的前景。在癌症治疗的新时代即将到来之际，本文强调了继续研究和合作的重要性，以便将这些创新的治疗方法从实验室带到临床。
