Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, 07743 Jena, Germany.
Jena Center for Soft Matter, Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.
Anal Chem. 2021 Dec 7;93(48):15805-15815. doi: 10.1021/acs.analchem.1c03116. Epub 2021 Nov 21.
The analytical ultracentrifuge (AUC) and the modern field of analytical ultracentrifugation found its inception approximately a century ago. We highlight the scope of its major experimental opportunities as a transport-based method, contemporary and up-and-coming investigation potential for polymers, polymer-drug conjugates, polymer assemblies, as well as medical nanoparticles. Special focus lies on molar mass estimates of unimeric polymeric species, self-assemblies in solution, and (co)localization of multicomponent systems in solution alongside the material-biofluid interactions. We close with present challenges and incentives for future research.
分析超速离心机（AUC）和分析超速离心领域大约在一个世纪前就已经出现了。我们强调了它作为一种基于传输的方法的主要实验机会的范围，包括聚合物、聚合物-药物偶联物、聚合物组装体以及医疗纳米颗粒的现代和新兴研究潜力。特别关注的是单体聚合物物种的摩尔质量估计、溶液中的自组装以及多组分系统在溶液中的（共）定位以及材料-生物流体相互作用。最后，我们讨论了当前的挑战和未来研究的激励因素。
