Li Wei, Zhou Siyu, Zou Da, Han Gengyu, Sun Zhuoran, Li Weishi
Orthopaedic Department, Peking University Third Hospital, Beijing, China.
Beijing Key Laboratory of Spinal Disease Research, Beijing, China.
Global Spine J. 2023 Jul;13(6):1612-1621. doi: 10.1177/21925682211043465. Epub 2021 Nov 20.
Retrospective study.
To evaluate the predictive effect of the 3 global sagittal parameters (Sagittal Vertical Axis [SVA], T1 Pelvic Angle [TPA], and relative TPA [rTPA]) in the surgical outcome of patients with adult degenerative scoliosis (ADS), then to define the optimum corrective goal based on the best of them.
117 ADS patients were included in this study and followed-up for an average of 3 years. Functional evaluation and radiographs were assessed preoperatively and postoperatively. The predictive accuracy of SVA, TPA, and relative TPA was analyzed through receiver operating characteristic (ROC) curve. The cutoff value of TPA was obtained at the maximal Youden index from ROC curve.
TPA most highly correlated with postoperative oswestry disability index (ODI). The best cutoff value of TPA was set at 19.3° (area under curve =0.701). TPA >19.3° was the highest risk factor in multivariate logistic regression analysis (OR = 7.124, = 0.022). Patients with TPA <19.3° at 3 months after operation showed a better ODI than those with TPA >19.3°. Correcting TPA less than 19.3° for patients with preoperative TPA >19.3° attributed to a better health related quality of life (HRQOL) and sagittal balance at last follow-up. The formula "Postoperative TPA = 0.923 × PI - 0.241 × postoperative LL - 0.593 × postoperative SS - 2.471 ( = 0.914, = 0.836, < .001)" described the relation between SS, LL, PI, and TPA.
TPA was a useful global parameter for the prediction of postoperative HRQOL for patients with ADS. Keeping TPA <19.3° could improve the postoperative HRQOL for ADS patients with preoperative TPA >19.3°, and TPA <19.3° could be an optimum correction target for patients with ADS.
回顾性研究。
评估3个整体矢状面参数(矢状面垂直轴[SVA]、T1骨盆角[TPA]和相对TPA[rTPA])对成人退变性脊柱侧凸(ADS)患者手术疗效的预测作用,进而基于其中最佳参数确定最佳矫正目标。
本研究纳入117例ADS患者,平均随访3年。术前及术后评估功能并进行X线片检查。通过受试者工作特征(ROC)曲线分析SVA、TPA和相对TPA的预测准确性。从ROC曲线的最大约登指数处获得TPA的截断值。
TPA与术后奥斯威斯利功能障碍指数(ODI)相关性最高。TPA的最佳截断值设定为19.3°(曲线下面积=0.701)。在多因素逻辑回归分析中,TPA>19.3°是最高风险因素(OR=7.124,P=0.022)。术后3个月时TPA<19.3°的患者ODI优于TPA>19.3°的患者。对于术前TPA>19.3°的患者,将TPA矫正至小于19.3°可使最终随访时的健康相关生活质量(HRQOL)和矢状面平衡更好。公式“术后TPA = 0.923×PI - 0.241×术后腰椎前凸(LL) - 0.593×术后骶骨倾斜角(SS) - 2.471(R=0.914,P=0.836,P<0.001)”描述了SS、LL、PI和TPA之间的关系。
TPA是预测ADS患者术后HRQOL的有用整体参数。对于术前TPA>19.3°的ADS患者,使TPA<19.3°可改善术后HRQOL,且TPA<19.3°可能是ADS患者的最佳矫正目标。