Department of Radiology, Stanford University, Stanford, CA, USA.
Lane Medical Library, Stanford University, Stanford, CA, USA.
J Cereb Blood Flow Metab. 2022 May;42(5):700-717. doi: 10.1177/0271678X211056702. Epub 2021 Nov 22.
Cerebrovascular reactivity (CVR), the capacity of the brain to increase cerebral blood flow (CBF) to meet changes in physiological demand, is an important biomarker to evaluate brain health. Typically, this brain "stress test" is performed by using a medical imaging modality to measure the CBF change between two states: at baseline and after vasodilation. However, since there are many imaging modalities and many ways to augment CBF, a wide range of CVR values have been reported. An understanding of CVR reproducibility is critical to determine the most reliable methods to measure CVR as a clinical biomarker. This review focuses on CVR reproducibility studies using neuroimaging techniques in 32 articles comprising 427 total subjects. The literature search was performed in PubMed, Embase, and Scopus. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We identified 5 factors of the experimental subjects (such as sex, blood characteristics, and smoking) and 9 factors of the measuring technique (such as the imaging modality, the type of the vasodilator, and the quantification method) that have strong effects on CVR reproducibility. Based on this review, we recommend several best practices to improve the reproducibility of CVR quantification in neuroimaging studies.
脑血管反应性（CVR）是大脑增加脑血流（CBF）以满足生理需求变化的能力，是评估大脑健康的重要生物标志物。通常，通过使用医学成像方式来测量两种状态之间的 CBF 变化来进行这种大脑“压力测试”：基线时和血管扩张后。然而，由于有许多成像方式和许多增加 CBF 的方法，因此已经报道了广泛的 CVR 值。了解 CVR 的可重复性对于确定测量 CVR 作为临床生物标志物的最可靠方法至关重要。本综述重点介绍了使用神经影像学技术进行的 32 篇文章中的 CVR 可重复性研究，这些文章共包含 427 名受试者。文献检索在 PubMed、Embase 和 Scopus 中进行。综述使用系统评价和荟萃分析的首选报告项目（PRISMA）进行。我们确定了对 CVR 可重复性有强烈影响的 5 个实验对象因素（如性别、血液特征和吸烟）和 9 个测量技术因素（如成像方式、血管扩张剂的类型和定量方法）。基于此综述，我们建议了一些最佳实践，以提高神经影像学研究中 CVR 定量的可重复性。
