Department of Clinical Psychology and Psychotherapy, Institute of Psychology, University of Goettingen.
Klinik Lueneburger Heide.
J Consult Clin Psychol. 2021 Oct;89(10):805-815. doi: 10.1037/ccp0000675.
Especially for adult patients with anorexia nervosa (AN), treatment response is generally low to moderate. The present study aimed to evaluate the efficacy of cognitive remediation therapy (CRT) as adjunctive treatment for AN regarding clinical and cognitive outcomes. In this randomized controlled superiority trial, 167 adult and adolescent (≥17 years) patients with AN were randomly allocated (1:1) to 10 weekly sessions of group therapy of either CRT (n = 82) or art therapy (ART; n = 85) as an adjunct to inpatient treatment-as-usual (TAU). Outcomes were assessed at baseline, end-of-treatment (10 weeks), and 6-month follow-up. Change in body mass index (BMI), eating disorder psychopathology, and health-related quality of life (QoL) from baseline to 6-month follow-up served as primary outcomes. Improvements in motivation to change and several indices of set-shifting and central coherence between baseline and end-of-treatment and between baseline and 6-month follow-up served as secondary outcomes. Analysis was by intention to treat. Treatment groups did not differ regarding change in BMI, eating disorder psychopathology, and health-related QoL from baseline to 6-month follow-up. Likewise, groups neither differed regarding improvements in these outcomes between baseline and end-of-treatment nor in motivation to change, set-shifting, and central coherence at any time, except for greater short-term improvements in one measure of set-shifting in the CRT group. CRT as an adjunct to inpatient TAU for AN was not efficacious in improving clinical and cognitive outcomes. The results do not support routine employment of CRT in inpatient treatment for AN. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
特别针对患有神经性厌食症（AN）的成年患者，治疗反应通常较低或中等。本研究旨在评估认知矫正治疗（CRT）作为 AN 的辅助治疗，针对临床和认知结果。在这项随机对照优势试验中，167 名成年和青少年（≥17 岁）AN 患者被随机分配（1:1）到每周 10 次的 CRT 组（n = 82）或艺术治疗（ART）组（n = 85），作为住院治疗的辅助治疗-常规（TAU）。在基线、治疗结束（10 周）和 6 个月随访时评估结局。从基线到 6 个月随访的体重指数（BMI）、饮食障碍病理和健康相关生活质量（QoL）的变化作为主要结局。从基线到治疗结束和从基线到 6 个月随访的动机改变和几种设定转换和中心连贯性的指数改善作为次要结局。分析是根据意向治疗进行的。治疗组在 BMI、饮食障碍病理和健康相关 QoL 方面从基线到 6 个月随访没有差异。同样，两组在这些结局方面也没有差异，无论是从基线到治疗结束的改善，还是在动机改变、设定转换和中心连贯性方面，除了 CRT 组的一种设定转换测量在短期内有更大的改善。CRT 作为 AN 住院 TAU 的辅助治疗在改善临床和认知结果方面无效。结果不支持 CRT 在 AN 住院治疗中的常规应用。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
