Department of Interventional Cardiology, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Cardiovascular Center, University Medical Center Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Am J Case Rep. 2021 Nov 22;22:e934190. doi: 10.12659/AJCR.934190.
BACKGROUND Kounis syndrome is a hypersensitive coronary disorder triggered by drugs, food, and environmental factors. A 38-year-old male patient with acetaminophen-induced type 1 Kounis syndrome is described. The purpose of this paper is to show that Kounis syndrome is a serious condition that may be linked to a common medication and that it should be recognized earlier in clinical practice. CASE REPORT We report a case of a 38-year-old male patient with chest discomfort, dyspnea, and hypotension following a paracetamol continuous infusion, as well as ST elevation on numerous leads during the episode. The diagnosis of drug-induced Kounis syndrome was made when the patient no longer had angina and the EKG returned to normal after the infusion was discontinued; the coronary angiography also showed no remarkable stenosis. CONCLUSIONS Kounis syndrome is a hypersensitive coronary disease that involves eosinophil and/or mast cell infiltrated coronary stent thrombosis, vasospastic angina, and allergic myocardial infarction. Although acetaminophen is widely used, acetaminophen-induced Kounis syndrome is uncommon and seldom documented. The necessity of detecting the distinct appearance earlier to give more suitable therapy is highlighted in this report.
Kounis 综合征是一种由药物、食物和环境因素引发的超敏性冠状动脉疾病。本文描述了一例由对乙酰氨基酚引起的 1 型 Kounis 综合征的 38 岁男性患者。本文旨在表明 Kounis 综合征是一种严重的疾病，可能与常见药物有关，在临床实践中应更早识别。
我们报告了一例 38 岁男性患者，在连续输注对乙酰氨基酚后出现胸痛、呼吸困难和低血压，以及多个导联上的 ST 段抬高。当患者不再出现心绞痛且停用输液后心电图恢复正常时，诊断为药物诱导的 Kounis 综合征；冠状动脉造影也未显示明显狭窄。
Kounis 综合征是一种超敏性冠状动脉疾病，涉及嗜酸性粒细胞和/或肥大细胞浸润的冠状动脉支架血栓形成、血管痉挛性心绞痛和过敏性心肌梗死。虽然对乙酰氨基酚被广泛使用，但由其引起的 Kounis 综合征并不常见，也很少有文献报道。本报告强调了更早发现这种特殊表现以给予更合适治疗的必要性。
