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The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells.

作者信息

Ito Naoto, Sakata Fumiya, Hachisu Masakazu, Nagata Kazuki, Ito Tomoka, Nomura Kurumi, Nagaoka Masanori, Inaba Keito, Hara Mutsuko, Nakano Nobuhiro, Nakajima Tadaaki, Yashiro Takuya, Nishiyama Chiharu

机构信息

Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Tokyo, Japan.

Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.

出版信息

Allergy. 2022 Mar;77(3):1054-1059. doi: 10.1111/all.15184. Epub 2021 Dec 7.

DOI:10.1111/all.15184
PMID:34807993
Abstract
摘要

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The Ccl17 gene encoding TARC is synergistically transactivated by PU.1 and IRF4 driven by the mammalian common promoter in dendritic cells.编码胸腺活化调节趋化因子（TARC）的Ccl17基因在树突状细胞中由哺乳动物共同启动子驱动，被PU.1和IRF4协同反式激活。
Allergy. 2022 Mar;77(3):1054-1059. doi: 10.1111/all.15184. Epub 2021 Dec 7.
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[Association of single nucleotide polymorphisms in TARC/CCL17 gene with Kawasaki disease and its clinical characteristics].[TARC/CCL17基因单核苷酸多态性与川崎病及其临床特征的关联]
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Identification of thymus and activation-regulated chemokine (TARC/CCL17) as a potential marker for early indication of disease and prediction of disease activity in drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS).鉴定胸腺激活调节趋化因子（TARC/CCL17）作为药物诱导的超敏反应综合征（DIHS）/伴有嗜酸性粒细胞增多和全身症状的药物疹（DRESS）疾病早期指标和疾病活动预测的潜在标志物。
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Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice.胸腺与激活调节趋化因子（TARC/CCL17）在小鼠皮内注射时可诱导以Th2为主导的炎症反应。
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Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain.对FDA批准的药物库进行筛选，发现了可阻断关节炎疼痛的CCL17抑制剂。
Sci Rep. 2025 Jul 23;15(1):26734. doi: 10.1038/s41598-025-12191-4.
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IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b+ cDC2 subsets during influenza virus infection.流感病毒感染期间，IRF4调节肺驻留CD11b + cDC2亚群的转录和功能异质性。
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