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艰难梭菌孢子萌发：从起始到 DPA 释放。

Clostridioides difficile spore germination: initiation to DPA release.

机构信息

Department of Biology, Texas A&M University, College Station, TX 77843, United States.

Department of Biology, Texas A&M University, College Station, TX 77843, United States.

出版信息

Curr Opin Microbiol. 2022 Feb;65:101-107. doi: 10.1016/j.mib.2021.11.001. Epub 2021 Nov 19.

DOI:10.1016/j.mib.2021.11.001
PMID:34808546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8792321/
Abstract

Germination by Clostridioides difficile spores is an essential step in pathogenesis. Spores are metabolically dormant forms of bacteria that resist severe conditions. Work over the last 10 years has elucidated that C. difficile spores germinate thorough a novel pathway. This review summarizes our understanding of C. difficile spore germination and the factors involved in germinant recognition, cortex degradation and DPA release.

摘要

艰难梭菌孢子的萌发是其发病机制中的一个重要步骤。孢子是细菌的一种代谢休眠形式，可以抵抗恶劣条件。过去 10 年来的研究工作阐明了艰难梭菌孢子通过一种新途径进行萌发。本文综述了我们对艰难梭菌孢子萌发的理解，以及涉及发芽剂识别、皮层降解和 DPA 释放的因素。

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本文引用的文献

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J Bacteriol. 2021 Oct 12;203(21):e0039421. doi: 10.1128/JB.00394-21. Epub 2021 Aug 23.
2
Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant.通过种内竞争共生体预防致命艰难梭菌感染。
mBio. 2021 Mar 30;12(2):e00522-21. doi: 10.1128/mBio.00522-21.
3
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Antimicrob Agents Chemother. 2023 May 1;65(5). doi: 10.1128/AAC.01431-20. Epub 2021 Mar 1.
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The Clostridioides difficile Cysteine-Rich Exosporium Morphogenetic Protein, CdeC, Exhibits Self-Assembly Properties That Lead to Organized Inclusion Bodies in Escherichia coli.艰难梭菌富含半胱氨酸的外孢子形态发生蛋白 CdeC 表现出自组装特性，导致大肠埃希菌中形成有组织的包涵体。
mSphere. 2020 Nov 18;5(6):e01065-20. doi: 10.1128/mSphere.01065-20.
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