Department of Pedodontics and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
J Indian Soc Pedod Prev Dent. 2021 Jul-Sep;39(3):303-309. doi: 10.4103/jisppd.jisppd_60_21.
Pulpotomy is a vital pulp therapy performed in carious pulp exposures in teeth in which the inflamed coronal pulp is removed and medicament is placed to conserve the vital root pulps. Recently, simvastatin which is a cholesterol-lowering drug has been found to be associated with the pulp regenerative potential.
The aim of this parallel two-arm randomized control trial was to evaluate and compare the clinical and radiographic efficacy of diode laser (DL) and simvastatin gel (SG) in pulpotomy of carious primary molars.
Hundred primary molars (in 98 children, 65 males, 33 females with age 4-8 years) requiring pulpotomy were randomized into the DL or SG group. Pulpotomy was performed as per the standardized protocol; thereafter, all teeth were restored with resin modified glass ionomer cement followed by stainless steel crowns. Follow-up evaluations were done at 3 and 12 months using clinical and radiographic criteria. Statistical analysis was done using Chi-square test at a significance level of 0.05.
At 12 months, out of 92 teeth available for clinical and radiographic evaluation by blinded evaluators, DL group showed clinical and radiographic success rates of 76.1% and 52.1%, while SG group showed 80.4% and 65.2% success rates, respectively. There was no statistically significant difference between the efficacy of two techniques clinically (P = 0.49) or radiographically (P = 0.30).
Both SG and DL had similar efficacy for primary tooth pulpotomy, clinically and radiographically after 12 months. Considering its ease of application and low-cost, SG can be recommended as a potential pulpotomy medicament in primary molars.
活髓切断术是在牙髓暴露于龋损时进行的一种重要的牙髓治疗方法，其中去除发炎的冠部牙髓，并放置药物以保留有活力的根髓。最近，发现他汀类药物辛伐他汀与牙髓再生潜力有关。
本平行双臂随机对照试验的目的是评估和比较二极管激光（DL）和辛伐他汀凝胶（SG）在龋齿乳磨牙活髓切断术中的临床和放射学疗效。
将 100 颗（98 名儿童，65 名男性，33 名女性，年龄 4-8 岁）需要活髓切断术的乳磨牙随机分为 DL 或 SG 组。按照标准化方案进行活髓切断术；此后，所有牙齿均用树脂改良型玻璃离子水门汀修复，然后用不锈钢冠修复。采用临床和放射学标准进行 3 个月和 12 个月的随访评估。采用卡方检验进行统计学分析，显著性水平为 0.05。
在 12 个月时，通过盲法评估者对 92 颗可进行临床和放射学评估的牙齿进行评估，DL 组的临床和放射学成功率分别为 76.1%和 52.1%，而 SG 组分别为 80.4%和 65.2%。两种技术在临床（P=0.49）或放射学（P=0.30）方面的疗效均无统计学差异。
在 12 个月时，SG 和 DL 对乳磨牙活髓切断术均具有相似的临床和放射学疗效。考虑到其易于应用和低成本，SG 可作为乳磨牙活髓切断术的一种潜在药物推荐。
