Söderberg O, Hellström S
Department of Otolaryngology & Head and Neck Surgery, University of Umeå, Sweden.
Acta Otolaryngol Suppl. 1987;442:50-3. doi: 10.3109/00016488709102839.
The effects of hyaluronan-coated polyethylene tympanostomy tubes on the tympanic membrane structure were investigated and compared with non-coated polyethylene tubes without the coating. The tubes were inserted into the tympanic membrane (TM) and removed 3 weeks later. After 3 weeks the tubes were reinserted. This tube insertion and removal and reinsertion sequence was repeated 4 times and the tympanic membrane structure was examined histologically at 3 weeks and 12 weeks later. The study did not reveal any differences regarding the thickness and light microscopical appearance when comparing the TMs with the hyaluronan-coated tubes to those with the non-coated polyethylene tubes. However, the present way of evaluating the effects of different tube materials may be too crude. In future experiments aimed at elucidating the effects of different surface coatings of tympanostomy tubes other experimental designs must be employed, e.g. fewer tube insertion sequences and less traumatizing extractions.
研究了透明质酸涂层聚乙烯鼓膜造孔管对鼓膜结构的影响，并与未涂层的聚乙烯管进行了比较。将这些管子插入鼓膜（TM），3周后取出。3周后重新插入管子。这种管子插入、取出和重新插入的顺序重复4次，并在3周和12周后对鼓膜结构进行组织学检查。与未涂层的聚乙烯管相比，在比较使用透明质酸涂层管的鼓膜和未涂层管的鼓膜时，研究未发现厚度和光学显微镜外观有任何差异。然而，目前评估不同管材效果的方法可能过于粗略。在未来旨在阐明鼓膜造孔管不同表面涂层效果的实验中，必须采用其他实验设计，例如减少管子插入顺序和减少创伤性取出。
