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氟伐他汀可减轻人肺细胞中的新型冠状病毒 2 型感染。

Fluvastatin mitigates SARS-CoV-2 infection in human lung cells.

作者信息

Zapatero-Belinchón Francisco J, Moeller Rebecca, Lasswitz Lisa, van Ham Marco, Becker Miriam, Brogden Graham, Rosendal Ebba, Bi Wenjie, Carriquí-Madroñal Belén, Islam Koushikul, Lenman Annasara, Gunesch Antonia P, Kirui Jared, Pietschmann Thomas, Överby Anna K, Jänsch Lothar, Gerold Gisa

机构信息

Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture Between the Medical School Hannover and the Helmholtz Centre for Infection Research, 30625 Hannover, Germany.

Department of Clinical Microbiology, Virology, Umeå University, 90185 Umeå, Sweden.

出版信息

iScience. 2021 Dec 17;24(12):103469. doi: 10.1016/j.isci.2021.103469. Epub 2021 Nov 18.

DOI:10.1016/j.isci.2021.103469
PMID:34812415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8599137/
Abstract

Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical outcome through modulation of immune responses is unknown. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that only fluvastatin inhibited low and high pathogenic coronaviruses and in a dose-dependent manner. Quantitative proteomics revealed that fluvastatin and other tested statins modulated the cholesterol synthesis pathway without altering innate antiviral immune responses in infected lung epithelial cells. However, fluvastatin treatment specifically downregulated proteins that modulate protein translation and viral replication. Collectively, these results support the notion that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin has a moderate beneficial effect on SARS-CoV-2 infection of human lung cells.

摘要

新冠肺炎患者的临床数据表明，用于治疗高胆固醇血症的他汀类药物疗法与更好的疾病转归相关。他汀类药物是直接影响病毒复制还是通过调节免疫反应影响临床结局尚不清楚。因此，我们研究了他汀类药物对人肺细胞中SARS-CoV-2感染的影响，发现只有氟伐他汀能以剂量依赖的方式抑制低致病性和高致病性冠状病毒。定量蛋白质组学显示，氟伐他汀和其他测试的他汀类药物调节胆固醇合成途径，而不改变受感染肺上皮细胞中的先天性抗病毒免疫反应。然而，氟伐他汀治疗特异性地下调了调节蛋白质翻译和病毒复制的蛋白质。总的来说，这些结果支持这样一种观点，即他汀类药物疗法对接触SARS-CoV-2的个体没有额外风险，并且氟伐他汀对人肺细胞的SARS-CoV-2感染有适度的有益作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/f0c8d35ca476/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/d60cf46f6435/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/bf49f65b2cd5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/f15d73f5f8b0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/7cb65526a0f0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/c46e38860943/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/f0c8d35ca476/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/d60cf46f6435/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/bf49f65b2cd5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/f15d73f5f8b0/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/7cb65526a0f0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/c46e38860943/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdd0/8710553/f0c8d35ca476/gr5.jpg

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本文引用的文献

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Signal Transduct Target Ther. 2021 May 8;6(1):180. doi: 10.1038/s41392-021-00574-8.
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Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.
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