Johannessen A C, Isacsson G, Nilsen R, Bergendal T
Acta Odontol Scand. 1986 Jun;44(3):185-92. doi: 10.3109/00016358609026572.
Cryostat sections from 14 surgical specimens were examined to determine whether selected factors of the immune response related to histopathological reactions are present in the palatal mucosa affected by hyperplastic denture stomatitis. By means of various immunological techniques the presence of IgG, IgA, IgM, complement factor C3c, receptors for the Fc region of IgG (FcR) and for complement factor C3b (C3bR), T lymphocytes, and macrophages were studied. The inflammatory infiltrate was mainly located in the papillary part of the lamina propria. IgG, IgA, and IgM appeared both in plasma cells and intercellularly. FcR, C3bR, and T lymphocytes were present in the areas with inflammatory cell infiltrate. Macrophages were found in the papillary part of the lamina propria and within the epithelium. The immunological response in the mucosa affected by denture stomatitis was in many respects similar to that of marginal and apical periodontitis. We conclude that hyperplastic denture stomatitis is a complex inflammatory lesion showing elements of both humoral and cellular immune responses.
对14份手术标本的低温恒温器切片进行检查，以确定在受增生性义齿性口炎影响的腭黏膜中是否存在与组织病理学反应相关的免疫反应选定因素。通过各种免疫技术，研究了IgG、IgA、IgM、补体因子C3c、IgG Fc区受体（FcR）、补体因子C3b受体（C3bR）、T淋巴细胞和巨噬细胞的存在情况。炎性浸润主要位于固有层的乳头部分。IgG、IgA和IgM出现在浆细胞内和细胞间。FcR、C3bR和T淋巴细胞存在于炎性细胞浸润区域。在固有层的乳头部分和上皮内发现了巨噬细胞。义齿性口炎影响的黏膜中的免疫反应在许多方面与边缘性和根尖周炎相似。我们得出结论，增生性义齿性口炎是一种复杂的炎性病变，表现出体液免疫和细胞免疫反应的成分。
