Martinez Adriane C, Silva Isabela M V, Berti Couto Soraya A, Gandra Rinaldo F, Rosa Edvaldo A R, Johann Aline C B R, Couto Souza Paulo H
School of Biological Sciences and Healthcare, Department of Dentristry, Western Paraná State University, CascavelBrazil.
School of Life Sciences, Department of Dentristry, Pontifícia Universidade Católica do Paraná, CuritibaBrazil.
J Oral Maxillofac Res. 2020 Nov 30;11(3):e3. doi: 10.5037/jomr.2020.11303. eCollection 2020 Jul-Sep.
The aim of presented cross-sectional and observational study was to determine the prevalence of late oral complications of patients with head and neck cancer who underwent radiotherapy, by clinical and laboratory analyses.
Fifty-five patients, 43 (78.2%) men and 12 (21.8%) women, mean age 60; range 38 to 87 years, who have completed radiotherapy for head and neck cancer for at least 6 months were enrolled. The presence of xerostomia, hyposalivation, oral candidiasis, and type of oral yeasts were correlated with post-radiotherapy period. A control group, age and gender matched, was used for comparisons. The Pearson's Chi-square or Fischer's exact test was used at a significance level of 5%.
The mean post-radiotherapy period was 32 months. The oral complications found were xerostomia (45/55, [81.8%]), hyposalivation (44/55 [80%]) and oral candidiasis (15/55 [27.2%]). Xerostomia and hyposalivation was statistically higher in the study group when compared to the control group (P < 0.05). The presence of yeast occurred in 39 (70.9%) of the patients in the study group, and was the most prevalent etiological agent in 25 (64.1%) of those patients (P < 0.05).
Xerostomia and hyposalivation were the more prevalent late oral complications related to radiotherapy. Oral candidiasis was also observed, although its prevalence was lower. The need for long-term dental follow-up of patients who underwent radiotherapy of the head and neck cancer is mandatory.
本横断面观察性研究旨在通过临床和实验室分析，确定接受放射治疗的头颈癌患者晚期口腔并发症的患病率。
纳入55例患者，其中男性43例（78.2%），女性12例（21.8%），平均年龄60岁；年龄范围为38至87岁，这些患者已完成头颈癌放射治疗至少6个月。口干症、唾液分泌减少、口腔念珠菌病的存在以及口腔酵母菌类型与放疗后时期相关。使用年龄和性别匹配的对照组进行比较。采用Pearson卡方检验或Fisher精确检验，显著性水平为5%。
放疗后的平均时间为32个月。发现的口腔并发症有口干症（45/55，[81.8%]）、唾液分泌减少（44/55 [80%]）和口腔念珠菌病（15/55 [27.2%]）。与对照组相比，研究组的口干症和唾液分泌减少在统计学上更高（P < 0.05）。研究组39例（70.9%）患者中出现酵母菌，其中25例（64.1%）患者中酵母菌是最常见的病原体（P < 0.05）。
口干症和唾液分泌减少是与放疗相关的更常见的晚期口腔并发症。也观察到了口腔念珠菌病，尽管其患病率较低。对头颈癌放疗患者进行长期牙科随访是必要的。
