Programa de Pós-Graduação Multicêntrico em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil; Laboratório de Inflamação e Metabolismo - LIM, CIPq Saúde, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil.
Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brazil.
Exp Gerontol. 2022 Jan;157:111630. doi: 10.1016/j.exger.2021.111630. Epub 2021 Nov 20.
Patients with chronic obstructive pulmonary disease (COPD) often present with sarcopenia, a condition marked by the loss in quality and quantity of muscle mass that can affect the strength of respiratory muscles. COPD and sarcopenia are also independently associated with oxidative stress. This study aimed to investigate whether oxidative stress biomarkers and respiratory muscle strength are associated with sarcopenia in COPD patients.
In a cross-sectional study, 86 elderly subjects, including subjects with and without COPD were assessed for body composition, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) and oxidative stress parameters [substances reactive to thiobarbituric acid (TBARS), ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase (CAT)].
The sample was mainly composed by males (72.1%) and eutrophic subjects. COPD-related sarcopenia was evidenced in 51.1% (22/43) of subjects with COPD. The highest TBARS and CAT, and lower MIP and MEP were associated with a high probability of having COPD-related sarcopenia. In the multivariate analysis, TBARS (OR: 4.89, 95% CI 1.52 to 15.54, p = 0.006), CAT (OR: 1.22, 95% CI 1.03 to 1.45, p = 0.020) and MEP (OR: 0.97, 95% CI 0.95 to 0.99, p = 0.020) were independent determinants of COPD-related sarcopenia.
The increase in oxidative stress-related factors and the reduction of respiratory muscle strength are associated with COPD-related sarcopenia.
慢性阻塞性肺疾病（COPD）患者常伴有肌肉减少症，这是一种以肌肉质量和数量减少为特征的疾病，可影响呼吸肌的力量。COPD 和肌肉减少症也与氧化应激独立相关。本研究旨在探讨氧化应激生物标志物和呼吸肌力量是否与 COPD 患者的肌肉减少症有关。
在一项横断面研究中，评估了 86 名老年受试者的身体成分、最大吸气压力（MIP）和最大呼气压力（MEP）以及氧化应激参数[硫代巴比妥酸反应物质（TBARS）、血浆还原能力（FRAP）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）]。
该样本主要由男性（72.1%）和营养良好的受试者组成。在 43 名 COPD 患者中，有 51.1%（22/43）患有 COPD 相关的肌肉减少症。TBARS 和 CAT 最高，MIP 和 MEP 最低与 COPD 相关的肌肉减少症发生的可能性较高有关。在多变量分析中，TBARS（OR：4.89，95%CI 1.52 至 15.54，p=0.006）、CAT（OR：1.22，95%CI 1.03 至 1.45，p=0.020）和 MEP（OR：0.97，95%CI 0.95 至 0.99，p=0.020）是 COPD 相关肌肉减少症的独立决定因素。
氧化应激相关因素的增加和呼吸肌力量的降低与 COPD 相关的肌肉减少症有关。
